A sesquiterpenoid tropolone and 1,2,3,4-tetrahydronaphthalene derivatives from Olax imbricata roots.
Cytotoxicity
Olax imbricata
Olaximbrisides A–D
Sesquiterpenoid
Tetrahydronaphthalene
Tropolone
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
11
09
2018
revised:
09
11
2018
accepted:
11
11
2018
pubmed:
16
11
2018
medline:
23
1
2019
entrez:
16
11
2018
Statut:
ppublish
Résumé
The methanol extract of Olax imbricata roots afforded one new sesquiterpenoid tropolone and three new 1,2,3,4-tetrahydronaphthalene derivatives, olaximbrisides A-D (1-4). Their structures were determined by 1D and 2D NMR experiments in combination of HRESIMS. The relative configurations were assigned by the NOESY experiments. The absolute configurations were established by a combination of X-ray diffraction analysis and electronic circular dichroism (ECD) experiments. All isolated compounds were evaluated for their cytotoxic effects against some cancer cell lines. Among them, compound 1 exhibited the cytotoxicities against MCF-7, HepG2 and LU cell lines with IC
Identifiants
pubmed: 30439445
pii: S0367-326X(18)31550-8
doi: 10.1016/j.fitote.2018.11.007
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Tetrahydronaphthalenes
0
Tropolone
7L6DL16P1T
tetralin
FT6XMI58YQ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-6Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.