High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype.
Journal
Translational oncology
ISSN: 1936-5233
Titre abrégé: Transl Oncol
Pays: United States
ID NLM: 101472619
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
06
09
2018
revised:
22
10
2018
accepted:
25
10
2018
pubmed:
16
11
2018
medline:
16
11
2018
entrez:
16
11
2018
Statut:
ppublish
Résumé
Steatohepatitis (SH) and SH-associated hepatocellular carcinoma (HCC) are of considerable clinical significance. SH is morphologically characterized by steatosis, liver cell ballooning, cytoplasmic aggregates termed Mallory-Denk bodies (MDBs), inflammation, and fibrosis at late stage. Disturbance of the keratin cytoskeleton and aggregation of keratins (KRTs) are essential for MDB formation. We analyzed livers of aged Krt18 Our analysis of the genetic profile of Krt18 We can prove that intermediate filaments and their binding partners are tightly linked to hepatic lipid metabolism and to hepatocarcinogenesis. We suggest KRT8/18 ratio as a novel HCC biomarker for HCC.
Sections du résumé
BACKGROUND & AIMS
OBJECTIVE
Steatohepatitis (SH) and SH-associated hepatocellular carcinoma (HCC) are of considerable clinical significance. SH is morphologically characterized by steatosis, liver cell ballooning, cytoplasmic aggregates termed Mallory-Denk bodies (MDBs), inflammation, and fibrosis at late stage. Disturbance of the keratin cytoskeleton and aggregation of keratins (KRTs) are essential for MDB formation.
METHODS
METHODS
We analyzed livers of aged Krt18
RESULTS
RESULTS
Our analysis of the genetic profile of Krt18
CONCLUSIONS
CONCLUSIONS
We can prove that intermediate filaments and their binding partners are tightly linked to hepatic lipid metabolism and to hepatocarcinogenesis. We suggest KRT8/18 ratio as a novel HCC biomarker for HCC.
Identifiants
pubmed: 30439626
pii: S1936-5233(18)30439-X
doi: 10.1016/j.tranon.2018.10.010
pmc: PMC6234703
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
256-268Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK099558
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
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