How safe is doxycycline for young children or for pregnant or breastfeeding women?
Children
Congenital anomaly
Dental staining
Doxycycline
Pregnancy
Teeth
Journal
Diagnostic microbiology and infectious disease
ISSN: 1879-0070
Titre abrégé: Diagn Microbiol Infect Dis
Pays: United States
ID NLM: 8305899
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
05
03
2018
revised:
15
09
2018
accepted:
25
09
2018
pubmed:
18
11
2018
medline:
13
4
2019
entrez:
17
11
2018
Statut:
ppublish
Résumé
Tetracycline antimicrobials entered into clinical usage in the late 1940s. Permanent dental staining from tetracyclines was first appreciated in 1956, eventually leading to avoidance of this class of antibiotics whenever possible in young children and pregnant or breastfeeding women. Doxycycline, introduced in 1967, binds calcium less avidly than prior tetracyclines and is regarded by some authorities as safe to prescribe for pregnant women and young children. Review of the available data, however, suggests that this interpretation may be incorrect or at least premature. In conclusion, until more definitive data are developed, doxycycline should continue to be only selectively prescribed for young children and pregnant or breastfeeding women for whom alternative, safer antibiotics are not available, and courses of treatment should be of as short a duration as possible.
Identifiants
pubmed: 30442509
pii: S0732-8893(18)30438-3
doi: 10.1016/j.diagmicrobio.2018.09.015
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Doxycycline
N12000U13O
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
238-242Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.