Selective colonization ability of human fecal microbes in different mouse gut environments.
Journal
The ISME journal
ISSN: 1751-7370
Titre abrégé: ISME J
Pays: England
ID NLM: 101301086
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
10
04
2018
accepted:
16
10
2018
revised:
10
10
2018
pubmed:
18
11
2018
medline:
7
8
2019
entrez:
17
11
2018
Statut:
ppublish
Résumé
Mammalian hosts constantly interact with diverse exogenous microbes, but only a subset of the microbes manage to colonize due to selective colonization resistance exerted by host genetic factors as well as the native microbiota of the host. An important question in microbial ecology and medical science is if such colonization resistance can discriminate closely related microbial species, or even closely related strains of the same species. Using human-mouse fecal microbiota transplantation and metagenomic shotgun sequencing, we reconstructed colonization patterns of human fecal microbes in mice with different genotypes (C57BL6/J vs. NSG) and with or without an intact gut microbiota. We found that mouse genotypes and the native mouse gut microbiota both exerted different selective pressures on exogenous colonizers: human fecal Bacteroides successfully established in the mice gut, however, different species of Bacteroides selectively enriched under different gut conditions, potentially due to a multitude of functional differences, ranging from versatility in nutrient acquisition to stress responses. Additionally, different clades of Bacteroides cellulosilyticus strains were selectively enriched in different gut conditions, suggesting that the fitness of conspecific microbial strains in a novel host environment could differ.
Identifiants
pubmed: 30442907
doi: 10.1038/s41396-018-0312-9
pii: 10.1038/s41396-018-0312-9
pmc: PMC6461746
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
805-823Subventions
Organisme : NIGMS NIH HHS
ID : DP2 GM126893
Pays : United States
Organisme : NIAID NIH HHS
ID : K22 AI119231
Pays : United States
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : 1 DP2 GM126893-01
Pays : International
Commentaires et corrections
Type : ErratumIn
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