Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy.
Animals
Antiviral Agents
/ therapeutic use
Carcinoma, Hepatocellular
/ immunology
Hepacivirus
/ physiology
Hepatitis C, Chronic
/ immunology
Humans
Immune Evasion
Immune System
/ drug effects
Immunomodulation
Immunotherapy
/ methods
Interferons
/ therapeutic use
Liver Neoplasms
/ immunology
Neoplasm Recurrence, Local
Virus Activation
Direct-acting antivirals
HCV
Hepatocellular carcinoma
Immune system
Journal
Archivum immunologiae et therapiae experimentalis
ISSN: 1661-4917
Titre abrégé: Arch Immunol Ther Exp (Warsz)
Pays: Switzerland
ID NLM: 0114365
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
31
01
2018
accepted:
08
11
2018
pubmed:
18
11
2018
medline:
6
7
2019
entrez:
17
11
2018
Statut:
ppublish
Résumé
The treatment of patients with chronic hepatitis C virus (HCV) infection has changed tremendously over the past 2 years, with an increasing variety of all-oral direct-acting antiviral (DAA) treatment regimens available for different HCV genotypes and distinct clinical settings. These treatments have significantly improved safety in patients with advanced liver disease compared with interferon (IFN)-based regimens. HCV modifies the human immune system to escape immunosurveillance via several mechanisms. One of the basic mechanisms of HCV is the ability to "switch" the immune response by reducing the activity of cells responsible for the elimination of virus-infected cells. IFN-free DAA treatment regimens provide a unique opportunity to assess the effect of HCV elimination on the immune system. Abrupt changes in the immune system can in some cases be responsible for two alarming processes: viral reactivation in patients with chronic hepatitis B and recurrence of hepatocellular carcinoma in patients with previous successful cancer treatment.
Identifiants
pubmed: 30443787
doi: 10.1007/s00005-018-0532-8
pii: 10.1007/s00005-018-0532-8
pmc: PMC6420452
doi:
Substances chimiques
Antiviral Agents
0
Interferons
9008-11-1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
79-88Références
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