Reactivity of CK7 across the spectrum of renal cell carcinomas with clear cells.
clear cell renal cell carcinoma
cytokeratin 7
immunohistochemistry
kidney
Journal
Histopathology
ISSN: 1365-2559
Titre abrégé: Histopathology
Pays: England
ID NLM: 7704136
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
20
08
2018
revised:
12
11
2018
accepted:
13
11
2018
pubmed:
18
11
2018
medline:
14
6
2019
entrez:
17
11
2018
Statut:
ppublish
Résumé
Current available data on cytokeratin 7 (CK7) immunostaining pattern in the clear cell renal cell carcinoma (RCC) spectrum is conflicting. The aim of this study was to assess CK7 immunoreactivity within the spectrum of clear cell renal neoplasms, including clear cell RCC, multicystic renal neoplasm of low malignant potential and clear cell papillary RCC-like tumours. We analysed two clones of CK7 and two tumour blocks for a total of 75 cases divided into five distinct groups: (i) low-grade clear cell RCC, (ii) high-grade clear cell RCC, (iii) multicystic renal neoplasm of low malignant potential, (iv) clear cell RCC with cystic changes and (v) clear cell papillary RCC-like tumours. We found the highest CK7 reactivity in low-grade clear cell RCC, multicystic renal neoplasm of low malignant potential and clear cell papillary RCC-like groups, ranging from 60% to 93%. Our findings show that CK7 immunoreactivity in clear cell RCC is variable, and the extent of staining depends on the grade and architectural growth patterns of the tumours.
Substances chimiques
Biomarkers, Tumor
0
Keratin-7
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
608-617Subventions
Organisme : Charles University Research Fund
ID : Q39
Organisme : Charles University Research Fund
ID : FN 00669806
Informations de copyright
© 2018 John Wiley & Sons Ltd.