Propensity for Intra-abdominal and Hepatic Adiposity Varies Among Ethnic Groups.
Absorptiometry, Photon
Adiposity
Black or African American
/ statistics & numerical data
Aged
Asian
/ statistics & numerical data
Body Composition
Ethnicity
/ statistics & numerical data
Female
Hawaii
/ ethnology
Hispanic or Latino
/ statistics & numerical data
Humans
Intra-Abdominal Fat
/ diagnostic imaging
Japan
/ ethnology
Liver
/ diagnostic imaging
Magnetic Resonance Imaging
Male
Metabolic Syndrome
/ ethnology
Native Hawaiian or Other Pacific Islander
/ statistics & numerical data
Prevalence
Torso
/ diagnostic imaging
United States
/ epidemiology
Weight Gain
White People
/ statistics & numerical data
Body Mass Index
Dual-Energy X-Ray Absorptiometry
Magnetic Resonance Imaging
Nonalcoholic Fatty Liver Disease
Journal
Gastroenterology
ISSN: 1528-0012
Titre abrégé: Gastroenterology
Pays: United States
ID NLM: 0374630
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
29
06
2018
revised:
17
10
2018
accepted:
01
11
2018
pubmed:
18
11
2018
medline:
4
4
2019
entrez:
17
11
2018
Statut:
ppublish
Résumé
We compared fat storage in the abdominal region among individuals from 5 different ethnic-racial groups to determine whether fat storage is associated with disparities observed in metabolic syndrome and other obesity-associated diseases. We collected data from 1794 participants in the Multiethnic Cohort Study (60-77 years old; of African, European [white], Japanese, Latino, or Native Hawaiian ancestry) with body mass index values of 17.1-46.2 kg/m Relative amounts of trunk, visceral, and liver fat varied significantly with ethnicity-they were highest in Japanese Americans, lowest in African Americans, and intermediate in the other groups. Compared with African Americans, the mean visceral fat area was 45% and 73% greater in Japanese American men and women, respectively, and the mean measurements of liver fat were 61% and 122% greater in Japanese American men and women. The visceral and hepatic adiposity associated with weight gain since participants were 21 years old varied in a similar pattern among ethnic-racial groups. In the mediation analysis, visceral and liver fat jointly accounted for a statistically significant fraction of the difference in metabolic syndrome prevalence, compared with white persons, for African Americans, Japanese Americans, and Native Hawaiian women, independently of total fat mass. In an analysis of data from the participants in the Multiethnic Cohort Study, we found extensive differences among ethnic-racial groups in the propensity to store fat intra-abdominally. This observation should be considered by clinicians in the prevention and early detection of metabolic disorders.
Sections du résumé
BACKGROUND & AIMS
We compared fat storage in the abdominal region among individuals from 5 different ethnic-racial groups to determine whether fat storage is associated with disparities observed in metabolic syndrome and other obesity-associated diseases.
METHODS
We collected data from 1794 participants in the Multiethnic Cohort Study (60-77 years old; of African, European [white], Japanese, Latino, or Native Hawaiian ancestry) with body mass index values of 17.1-46.2 kg/m
RESULTS
Relative amounts of trunk, visceral, and liver fat varied significantly with ethnicity-they were highest in Japanese Americans, lowest in African Americans, and intermediate in the other groups. Compared with African Americans, the mean visceral fat area was 45% and 73% greater in Japanese American men and women, respectively, and the mean measurements of liver fat were 61% and 122% greater in Japanese American men and women. The visceral and hepatic adiposity associated with weight gain since participants were 21 years old varied in a similar pattern among ethnic-racial groups. In the mediation analysis, visceral and liver fat jointly accounted for a statistically significant fraction of the difference in metabolic syndrome prevalence, compared with white persons, for African Americans, Japanese Americans, and Native Hawaiian women, independently of total fat mass.
CONCLUSIONS
In an analysis of data from the participants in the Multiethnic Cohort Study, we found extensive differences among ethnic-racial groups in the propensity to store fat intra-abdominally. This observation should be considered by clinicians in the prevention and early detection of metabolic disorders.
Identifiants
pubmed: 30445012
pii: S0016-5085(18)35263-6
doi: 10.1053/j.gastro.2018.11.021
pmc: PMC6409195
mid: NIHMS1512399
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
966-975.e10Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001855
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA071789
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA164973
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA168530
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000130
Pays : United States
Informations de copyright
Copyright © 2019 AGA Institute. Published by Elsevier Inc. All rights reserved.
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