Nasal allergen-neutralizing IgG
Adult
Allergens
/ immunology
Antibodies, Neutralizing
/ immunology
B-Lymphocytes, Regulatory
/ immunology
Biomarkers
Desensitization, Immunologic
Female
Humans
Immunoglobulin E
/ immunology
Immunoglobulin G
/ immunology
Male
Middle Aged
Nasal Mucosa
/ immunology
Phleum
/ immunology
Pollen
/ immunology
Rhinitis, Allergic, Seasonal
/ immunology
Biomarkers of allergen immunotherapy
IgA(1)
IgA(2)
IgE-facilitated allergen binding
IgG(4)
allergic rhinoconjunctivitis with and without asthma
blocking antibodies
subcutaneous immunotherapy
Journal
The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
31
10
2017
revised:
19
09
2018
accepted:
28
09
2018
pubmed:
18
11
2018
medline:
17
3
2020
entrez:
17
11
2018
Statut:
ppublish
Résumé
Grass pollen subcutaneous immunotherapy (SCIT) is associated with induction of serum IgG We sought to determine whether SCIT induces nasal allergen-specific IgG In a cross-sectional controlled study, nasal fluid and sera were collected during the grass pollen season from 10 SCIT-treated patients, 13 untreated allergic patients (with seasonal allergic rhinitis [SAR]), and 12 nonatopic control subjects. Nasal and serum IgE and IgG Nasal and serum Phl p 1- and Phl p 5-specific IgE levels were increased in patients with SAR compared to nonatopic control subjects (all, P < .001) and SCIT-treated patients (nasal, P < .001; serum Phl p 5, P = .073). Nasal IgG For the first time, we show that nasal IgG
Sections du résumé
BACKGROUND
Grass pollen subcutaneous immunotherapy (SCIT) is associated with induction of serum IgG
OBJECTIVE
We sought to determine whether SCIT induces nasal allergen-specific IgG
METHODS
In a cross-sectional controlled study, nasal fluid and sera were collected during the grass pollen season from 10 SCIT-treated patients, 13 untreated allergic patients (with seasonal allergic rhinitis [SAR]), and 12 nonatopic control subjects. Nasal and serum IgE and IgG
RESULTS
Nasal and serum Phl p 1- and Phl p 5-specific IgE levels were increased in patients with SAR compared to nonatopic control subjects (all, P < .001) and SCIT-treated patients (nasal, P < .001; serum Phl p 5, P = .073). Nasal IgG
CONCLUSION
For the first time, we show that nasal IgG
Identifiants
pubmed: 30445057
pii: S0091-6749(18)31595-1
doi: 10.1016/j.jaci.2018.09.039
pii:
doi:
Substances chimiques
Allergens
0
Antibodies, Neutralizing
0
Biomarkers
0
Immunoglobulin G
0
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1067-1076Subventions
Organisme : Medical Research Council
ID : G0601303
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1000758
Pays : United Kingdom
Informations de copyright
Copyright © 2018. Published by Elsevier Inc.