Caffeine improves contrast sensitivity of freely moving rats.
Caffeine
Contrast sensitivity
Rat
Spatial frequency
Vision
Journal
Physiology & behavior
ISSN: 1873-507X
Titre abrégé: Physiol Behav
Pays: United States
ID NLM: 0151504
Informations de publication
Date de publication:
01 02 2019
01 02 2019
Historique:
received:
22
05
2018
revised:
06
11
2018
accepted:
12
11
2018
pubmed:
18
11
2018
medline:
21
3
2020
entrez:
17
11
2018
Statut:
ppublish
Résumé
Caffeine (1, 3, 7-trimethylxanthine) is a well-known central nervous system stimulant that affects various brain functions such as attention, memory and sensation. However, it remains unclear whether and how caffeine modulates visual ability such as contrast sensitivity (CS) and the CS-spatial frequency (SF) relationship. To investigate these points, we tested the effects of caffeine on the perceptual CS of rats under three SF conditions. CS was measured using a two-alternative forced choice (2AFC) grating detection task combined with a staircase method. Intraperitoneal administration of caffeine 30 min prior to the task improved CS in an SF-dependent manner, in which the improving effect was observed at 0.1 cycles/degree (cpd) of the optimal SF for rats but not at 0.5 or 1 cpd. We concluded that caffeine, a representative ingredient contained in foods or drinks consumed daily, leads to an improvement of perceptual visual sensitivity.
Identifiants
pubmed: 30445067
pii: S0031-9384(18)31015-1
doi: 10.1016/j.physbeh.2018.11.014
pii:
doi:
Substances chimiques
Central Nervous System Stimulants
0
Caffeine
3G6A5W338E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111-117Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.