Synergistic effect of Si-hydroxyapatite coating and VEGF adsorption on Ti6Al4V-ELI scaffolds for bone regeneration in an osteoporotic bone environment.
Alloys
Animals
Bone Regeneration
/ drug effects
Cell Line
Cell Proliferation
/ drug effects
Durapatite
/ chemistry
Endothelial Cells
/ metabolism
Female
Mice
Osteoblasts
/ metabolism
Osteoporosis
/ drug therapy
Sheep
Silicon
/ chemistry
Swine
Titanium
/ chemistry
Vascular Endothelial Growth Factor A
/ chemistry
Bone regeneration
Osteoporosis
Scaffold
Silicon hydroxyapatite
VEGF
Journal
Acta biomaterialia
ISSN: 1878-7568
Titre abrégé: Acta Biomater
Pays: England
ID NLM: 101233144
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
received:
23
07
2018
revised:
07
11
2018
accepted:
12
11
2018
pubmed:
18
11
2018
medline:
30
1
2020
entrez:
17
11
2018
Statut:
ppublish
Résumé
The osteogenic and angiogenic responses to metal macroporous scaffolds coated with silicon substituted hydroxyapatite (SiHA) and decorated with vascular endothelial growth factor (VEGF) have been evaluated in vitro and in vivo. Ti6Al4V-ELI scaffolds were prepared by electron beam melting and subsequently coated with Ca
Identifiants
pubmed: 30445158
pii: S1742-7061(18)30671-8
doi: 10.1016/j.actbio.2018.11.017
pii:
doi:
Substances chimiques
Alloys
0
Vascular Endothelial Growth Factor A
0
titanium alloy (TiAl6V4)
12743-70-3
Durapatite
91D9GV0Z28
Titanium
D1JT611TNE
Silicon
Z4152N8IUI
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
456-466Informations de copyright
Copyright © 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.