Discovery, synthesis of novel fusidic acid derivatives possessed amino-terminal groups at the 3-hydroxyl position with anticancer activity.

Animals Antineoplastic Agents / chemical synthesis Apoptosis / drug effects Cell Cycle / drug effects Cell Line, Tumor Drug Design Drug Screening Assays, Antitumor Fusidic Acid / chemical synthesis Heterografts Humans Mice Molecular Structure Structure-Activity Relationship
Anti-tumor activity Apoptosis Derivatives Fusidic acid Synthesis

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
15 Jan 2019
Historique:
received: 14 09 2018
revised: 25 10 2018
accepted: 27 10 2018
pubmed: 18 11 2018
medline: 5 2 2019
entrez: 17 11 2018
Statut: ppublish

Résumé

A series of novel fusidic acid (FA) derivatives were synthesized and screened for their in vitro cytotoxicity against the Hela, U87, KBV and MKN45 cancer cell lines. Selected FA derivatives with anti-tumor activity were firstly identified including compound 4, which exhibited good anti-proliferative activity with IC

Identifiants

DOI: 10.1016/j.ejmech.2018.10.059 PMID: 30445262
pubmed: 30445262
pii: S0223-5234(18)30936-X
doi: 10.1016/j.ejmech.2018.10.059
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Fusidic Acid 59XE10C19C

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

122-131

Informations de copyright

Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Auteurs

Jingxuan Ni (J)

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China.

Mengqi Guo (M)

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China.

Yucheng Cao (Y)

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China.

Lei Lei (L)

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China.

Kangli Liu (K)

Institute of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, PR China.

Binghua Wang (B)

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China.

Fangfang Lu (F)

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China.

Rong Zhai (R)

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China.

Xiangwei Gao (X)

Institute of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, PR China.

Chunhong Yan (C)

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA, 30912, USA.

Hongbo Wang (H)

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China. Electronic address: hongbowangyt@gmail.com.

Yi Bi (Y)

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China. Electronic address: beeyee_413@163.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Discovery, synthesis of novel fusidic acid...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Discovery, synthesis of novel fusidic acid...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Discovery, synthesis of novel fusidic acid...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Discovery, synthesis of novel fusidic acid...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Discovery, synthesis of novel fusidic acid...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Discovery, synthesis of novel fusidic acid...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Discovery, synthesis of novel fusidic acid...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Acide fusidique › Discovery, synthesis of novel fusidic acid...
questionsmedicales.fr › Régions du corps › Transplants › Hétérogreffes › Discovery, synthesis of novel fusidic acid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Discovery, synthesis of novel fusidic acid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Discovery, synthesis of novel fusidic acid...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Discovery, synthesis of novel fusidic acid...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Discovery, synthesis of novel fusidic acid...