Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gα

Animals COS Cells Cell Movement Chlorocebus aethiops GTP-Binding Protein alpha Subunits, G12-G13 / metabolism GTP-Binding Protein alpha Subunits, Gq-G11 / metabolism GTP-Binding Protein beta Subunits / metabolism GTP-Binding Protein gamma Subunits / metabolism Guanine Nucleotide Exchange Factors / metabolism HEK293 Cells HeLa Cells Humans MCF-7 Cells Signal Transduction
FR900359 G protein G protein–coupled receptor (GPCR) G13 Gbetagamma Gq P-REX1 Ras-related C3 botulinum toxin substrate 1 (Rac1) Rho (Rho GTPase) cell migration cell signaling guanine nucleotide exchange factor (GEF) heterotrimeric G protein regulator of G protein signaling (RGS)

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
11 01 2019
Historique:
received: 15 10 2018
revised: 12 11 2018
pubmed: 18 11 2018
medline: 6 5 2019
entrez: 18 11 2018
Statut: ppublish

Résumé

G protein-coupled receptors stimulate Rho guanine nucleotide exchange factors that promote mammalian cell migration. Rac and Rho GTPases exert opposing effects on cell morphology and are stimulated downstream of Gβγ and Gα

Identifiants

DOI: 10.1074/jbc.RA118.006254 PMID: 30446620 PMC: PMC6333895
pubmed: 30446620
pii: S0021-9258(20)40370-9
doi: 10.1074/jbc.RA118.006254
pmc: PMC6333895
doi:

Substances chimiques

G-protein Beta gamma 0
GTP-Binding Protein beta Subunits 0
GTP-Binding Protein gamma Subunits 0
Guanine Nucleotide Exchange Factors 0
PREX1 protein, human 0
GTP-Binding Protein alpha Subunits, G12-G13 EC 3.6.5.1
GTP-Binding Protein alpha Subunits, Gq-G11 EC 3.6.5.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

531-546

Subventions

Organisme : NCI NIH HHS
ID : R01 CA221289
Pays : United States

Informations de copyright

© 2019 Cervantes-Villagrana et al.

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Auteurs

Rodolfo Daniel Cervantes-Villagrana (RD)

From the Departments of Pharmacology and.
ORCID: 0000-0002-6599-7994

Sendi Rafael Adame-García (SR)

Cell Biology, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), 07360 Mexico City, Mexico.

Irving García-Jiménez (I)

Cell Biology, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), 07360 Mexico City, Mexico.

Víctor Manuel Color-Aparicio (VM)

From the Departments of Pharmacology and.

Yarely Mabell Beltrán-Navarro (YM)

From the Departments of Pharmacology and.

Gabriele M König (GM)

the University of Bonn, Institute of Pharmaceutical Biology, 53115 Bonn, Germany, and.

Evi Kostenis (E)

the University of Bonn, Institute of Pharmaceutical Biology, 53115 Bonn, Germany, and.
ORCID: 0000-0001-8284-5514

Guadalupe Reyes-Cruz (G)

Cell Biology, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), 07360 Mexico City, Mexico.

J Silvio Gutkind (JS)

the Moores Cancer Center and Department of Pharmacology, University of California, San Diego, La Jolla, California 92093.

José Vázquez-Prado (J)

From the Departments of Pharmacology and jvazquez@cinvestav.mx.
ORCID: 0000-0001-5797-6643

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Gβγ signaling to the chemotactic effector...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Cellules COS › Gβγ signaling to the chemotactic effector...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Gβγ signaling to the chemotactic effector...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Gβγ signaling to the chemotactic effector...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines G hétérotrimériques › Sous-unités alpha des protéines G › Sous-unités alpha G12-G13 des protéines G › Gβγ signaling to the chemotactic effector...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines G hétérotrimériques › Sous-unités alpha des protéines G › Sous-unités alpha Gq-G11 des protéines G › Gβγ signaling to the chemotactic effector...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines G hétérotrimériques › Sous-unités bêta des protéines G › Gβγ signaling to the chemotactic effector...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines G hétérotrimériques › Sous-unités gamma des protéines G › Gβγ signaling to the chemotactic effector...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Facteurs d'échange de nucléotides guanyliques › Gβγ signaling to the chemotactic effector...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Gβγ signaling to the chemotactic effector...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HeLa › Gβγ signaling to the chemotactic effector...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gβγ signaling to the chemotactic effector...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cellules MCF-7 › Gβγ signaling to the chemotactic effector...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Gβγ signaling to the chemotactic effector...