Neurological syndrome in goats associated with Ipomoea trifida and Ipomoea carnea containing calystegines.
Calystegines
Goat
Ipomoea carnea
Ipomoea trifida
Nicaragua
Poisoning
Journal
Toxicon : official journal of the International Society on Toxinology
ISSN: 1879-3150
Titre abrégé: Toxicon
Pays: England
ID NLM: 1307333
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
16
09
2018
revised:
07
11
2018
accepted:
09
11
2018
pubmed:
18
11
2018
medline:
12
1
2019
entrez:
18
11
2018
Statut:
ppublish
Résumé
A disease characterized by ataxia, tremors and nystagmus had been observed in goats in Nicaragua. The main histologic lesions were loss and neuronal vacuolation of Purkinje cells and Wallerian-like degeneration mainly in the cerebellum, suggesting a glycoprotein storage disease. Ipomoea carnea and Ipomoea trifida found in the paddocks were negative for swainsonine, but contained calystegines at 0.02% and 0.06% suggesting that the disease was caused by these substances, which are competitive inhibitors of β-glucosidase and α-galactosidase activities.
Identifiants
pubmed: 30447273
pii: S0041-0101(18)31012-2
doi: 10.1016/j.toxicon.2018.11.291
pii:
doi:
Substances chimiques
Tropanes
0
calystegin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8-11Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.