Physiological Effect of Prone Position in Children with Severe Bronchiolitis: A Randomized Cross-Over Study (BRONCHIO-DV).
esophageal pressure
noninvasive ventilation
prone position
viral bronchiolitis
work of breathing
Journal
The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
21
06
2018
revised:
21
09
2018
accepted:
26
09
2018
pubmed:
19
11
2018
medline:
28
10
2019
entrez:
19
11
2018
Statut:
ppublish
Résumé
To assess the effect of the prone position on physiological measures, including inspiratory effort, metabolic cost of breathing, and neural drive to the diaphragm as compared with the supine position in infants with severe bronchiolitis requiring noninvasive ventilation. Fourteen infants, median age 33 days (IQR [first and third quartiles], 25-58) were randomized to receive 7 cmH Median esophageal pressure-time product per minute was significantly lower in the prone position than in the supine position (227 cmH This study suggests a benefit of the prone position for infants with severe bronchiolitis requiring noninvasive ventilation by significantly decreasing the inspiratory effort and the metabolic cost of breathing. Further studies are needed to evaluate the potential impact of these physiological findings in a larger population. Clinicaltrials.gov: NCT02602678.
Identifiants
pubmed: 30448014
pii: S0022-3476(18)31401-X
doi: 10.1016/j.jpeds.2018.09.066
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT02602678']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112-119.e4Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.