Can the gut be the missing piece in uncovering PD pathogenesis?

Animals Brain / physiopathology Enteric Nervous System / physiopathology Gastrointestinal Diseases / physiopathology Gastrointestinal Microbiome / physiology Humans Inflammation / physiopathology Intestinal Mucosa / physiopathology Parkinson Disease / physiopathology
Enteric nervous system Gut microbiota Gut-brain axis Inflammation Intestinal epithelial barrier Parkinson's disease

Journal

Parkinsonism & related disorders
ISSN: 1873-5126
Titre abrégé: Parkinsonism Relat Disord
Pays: England
ID NLM: 9513583

Informations de publication

Date de publication:
02 2019
Historique:
received: 14 07 2018
revised: 25 10 2018
accepted: 09 11 2018
pubmed: 19 11 2018
medline: 27 3 2020
entrez: 19 11 2018
Statut: ppublish

Résumé

It is now well established that Parkinson's disease (PD) is not only a movement disorder of the CNS but also a gastrointestinal disorder affecting the enteric nervous system (ENS). The gut-brain axis is a bidirectional communication between the brain and the gastrointestinal tract, which comprises besides the CNS and the ENS, the intestinal epithelial barrier, the intestinal microbiota and the enteroendocrine systems. In this review, we present the clinical and pathological evidence suggesting that the gut-brain axis is dysfunctional in PD by discussing the possible role of gut microbiota, inflammation and permeability in the development of the disease.

Identifiants

DOI: 10.1016/j.parkreldis.2018.11.014 PMID: 30448099
pubmed: 30448099
pii: S1353-8020(18)30499-1
doi: 10.1016/j.parkreldis.2018.11.014
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

26-31

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Guillaume Chapelet (G)

Inserm, U1235, Faculté de Médecine, 1 rue Gaston Veil, F-44035 Nantes, France; University Nantes, Faculté de Médecine, 1 rue Gaston Veil, F-44035 Nantes, France; CHU Nantes, Clinical Gerontology Department, Bd Jacques Monod, F-44093 Nantes, France.

Laurène Leclair-Visonneau (L)

Inserm, U1235, Faculté de Médecine, 1 rue Gaston Veil, F-44035 Nantes, France; University Nantes, Faculté de Médecine, 1 rue Gaston Veil, F-44035 Nantes, France; CHU Nantes, Clinical Gerontology Department, Bd Jacques Monod, F-44093 Nantes, France; CHU Nantes, Department of Clinical Neurophysiology, Bd Jacques Monod, F-44093 Nantes, France.

Thomas Clairembault (T)

Inserm, U1235, Faculté de Médecine, 1 rue Gaston Veil, F-44035 Nantes, France; University Nantes, Faculté de Médecine, 1 rue Gaston Veil, F-44035 Nantes, France.

Michel Neunlist (M)

Inserm, U1235, Faculté de Médecine, 1 rue Gaston Veil, F-44035 Nantes, France; University Nantes, Faculté de Médecine, 1 rue Gaston Veil, F-44035 Nantes, France.

Pascal Derkinderen (P)

Inserm, U1235, Faculté de Médecine, 1 rue Gaston Veil, F-44035 Nantes, France; University Nantes, Faculté de Médecine, 1 rue Gaston Veil, F-44035 Nantes, France; CHU Nantes, Clinical Gerontology Department, Bd Jacques Monod, F-44093 Nantes, France; CHU Nantes, Department of Neurology, Nantes, Bd Jacques Monod, F-44093 Nantes, France. Electronic address: pascal.derkinderen@chu-nantes.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Can the gut be the missing piece in uncovering...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Can the gut be the missing piece in uncovering...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Système nerveux autonome › Système nerveux entérique › Can the gut be the missing piece in uncovering...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Can the gut be the missing piece in uncovering...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Can the gut be the missing piece in uncovering...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Can the gut be the missing piece in uncovering...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Can the gut be the missing piece in uncovering...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Can the gut be the missing piece in uncovering...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Can the gut be the missing piece in uncovering...