Benzofuran derivatives and their anti-tubercular, anti-bacterial activities.
Anti-bacterial
Anti-mycobacterial
Anti-tubercular
Benzofuran
Hybrid compounds
Structure-activity relationship
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
15 Jan 2019
15 Jan 2019
Historique:
received:
09
10
2018
revised:
03
11
2018
accepted:
09
11
2018
pubmed:
19
11
2018
medline:
5
2
2019
entrez:
19
11
2018
Statut:
ppublish
Résumé
Benzofuran is a fundamental structural unit in a variety of biologically active natural products, and its derivatives display various biological properties. Some benzofuran derivatives possess unique anti-tubercular and anti-bacterial action mechanism, and exhibit excellent in vitro and in vivo activities against both drug-sensitive and drug-resistant pathogens. Moreover, several benzofuran derivatives have already used in clinics for the treatment of various diseases. Thus, benzofuran is a useful pharmacophore to develop new anti-tubercular and anti-bacterial drugs. This review covers the recent advances of benzofuran derivatives as potential anti-tubercular and anti-bacterial agents, and the structure-activity relationship is also discussed to pave the way for the further rational development of this kind of derivatives.
Identifiants
pubmed: 30448416
pii: S0223-5234(18)30983-8
doi: 10.1016/j.ejmech.2018.11.025
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antitubercular Agents
0
Benzofurans
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
266-276Informations de copyright
Copyright © 2018 Elsevier Masson SAS. All rights reserved.