Non-targeted metabolomic analysis on multidrug resistance hepatocellular carcinoma cell and reversal effect of annonaceous acetogenins.
Acetogenins
/ pharmacology
Annonaceae
/ chemistry
Antineoplastic Agents, Phytogenic
/ pharmacology
Carcinoma, Hepatocellular
/ drug therapy
Cell Line, Tumor
Drug Resistance, Multiple
/ drug effects
Drug Resistance, Neoplasm
/ drug effects
Drug Screening Assays, Antitumor
Humans
Liver Neoplasms
/ drug therapy
Metabolic Networks and Pathways
/ drug effects
Metabolomics
/ instrumentation
Annonaceous acetogenins
Hepatocellular carcinoma
Metabolomics
Multidrug resistance
Journal
Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336
Informations de publication
Date de publication:
05 Feb 2019
05 Feb 2019
Historique:
received:
26
05
2018
revised:
30
08
2018
accepted:
21
10
2018
pubmed:
19
11
2018
medline:
20
3
2019
entrez:
19
11
2018
Statut:
ppublish
Résumé
Multidrug-resistance (MDR) has been shown to play a critical role in the development of many diseases. In this study, we used metabolomic method to evaluate the MDR in hepatocellular carcinoma, and investigate regulatory of annonaceous acetogenins on MDR of hepatocellular carcinoma. Multivariate statistical analysis revealed that the MDR of SMMC 7721 together with changes in glutathione metabolism, arginine and proline metabolism, sphingolipid metabolism. Annonaceous acetogenins impact these metabolism pathways. Metabolic pathway analysis coupled with stoichiometry analysis can be an effective tool to understand MDR mechanism and to potentially find new MDR reversal agents.
Identifiants
pubmed: 30448539
pii: S0731-7085(18)31255-X
doi: 10.1016/j.jpba.2018.10.037
pii:
doi:
Substances chimiques
Acetogenins
0
Antineoplastic Agents, Phytogenic
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
489-495Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.