Neuroprotective effects of triterpenoid saponins from Medicago sativa L. against H

Cell Line, Tumor Cell Survival / drug effects Chromans / pharmacology Humans Hydrogen Peroxide / pharmacology Medicago sativa / chemistry Neuroprotective Agents / chemistry Oxidative Stress / drug effects Saponins / chemistry Triterpenes / chemistry
Medicago sativa L. Neuroprotective effects SH-SY5Y cells Triterpenoid saponins

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
03 2019
Historique:
received: 04 10 2018
revised: 07 11 2018
accepted: 09 11 2018
pubmed: 19 11 2018
medline: 2 11 2019
entrez: 19 11 2018
Statut: ppublish

Résumé

Medicago sativa L. is a forage legume plant widely distributed in all continents. Six new triterpenoid saponins, Medicagosides A-F (1-6) and five known ones (7-11) were isolated from M. sativa. Their structures were determined via HRESIMS, 1D and 2D NMR analysis. Biologically, all the isolates displayed neuroprotective activities against H

Identifiants

DOI: 10.1016/j.bioorg.2018.11.008 PMID: 30448725
pubmed: 30448725
pii: S0045-2068(18)31131-3
doi: 10.1016/j.bioorg.2018.11.008
pii:
doi:

Substances chimiques

Chromans 0
Neuroprotective Agents 0
Saponins 0
Triterpenes 0
Hydrogen Peroxide BBX060AN9V
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid S18UL9710X

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

468-476

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Xue-Gui Liu (XG)

College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, People's Republic of China; Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, People's Republic of China.

Yu-Qiu Sun (YQ)

College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, People's Republic of China.

Jun Bian (J)

College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, People's Republic of China.

Ting Han (T)

College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, People's Republic of China.

Dan-Dan Yue (DD)

College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, People's Republic of China.

Dan-Qi Li (DQ)

College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, People's Republic of China; Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, People's Republic of China. Electronic address: lidanqi@yeah.net.

Pin-Yi Gao (PY)

College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, People's Republic of China; Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, People's Republic of China. Electronic address: gpy1981@126.com.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Neuroprotective effects of triterpenoid...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Neuroprotective effects of triterpenoid...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Chromanes › Neuroprotective effects of triterpenoid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Neuroprotective effects of triterpenoid...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Neuroprotective effects of triterpenoid...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Fabaceae › Medicago › Medicago sativa › Neuroprotective effects of triterpenoid...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Neuroprotective effects of triterpenoid...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Neuroprotective effects of triterpenoid...
questionsmedicales.fr › Glucides › Hétérosides › Saponines › Neuroprotective effects of triterpenoid...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Triterpènes › Neuroprotective effects of triterpenoid...