Neuromedin U Does Not Act as a Decretin in Rats.
decretin
glucagon-like peptide 1
insulin secretion
neuromedin U
neuromedin U receptor 1 and 2
type 2 diabetes
Journal
Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170
Informations de publication
Date de publication:
05 03 2019
05 03 2019
Historique:
received:
28
06
2018
revised:
25
09
2018
accepted:
19
10
2018
pubmed:
20
11
2018
medline:
12
5
2020
entrez:
20
11
2018
Statut:
ppublish
Résumé
Studies on isolated pancreatic islets suggest that neuromedin U (NMU), a brain and gastrointestinal peptide, acts as a decretin hormone, inhibiting glucose-stimulated insulin secretion. We investigated whether this effect could be reproduced in vivo and in isolated perfused rat pancreas. Unlike the incretin hormone, glucagon-like peptide 1 (GLP-1), intravenous NMU administration had no effects on blood glucose and plasma insulin and glucagon in vivo. Moreover, NMU neither changed insulin, glucagon, or somatostatin secretion from isolated perfused rat pancreas, nor affected GLP-1-stimulated insulin and somatostatin secretion. For NMU to act as a decretin hormone, its secretion should increase following glucose ingestion; however, glucose did not affect NMU secretion from isolated perfused rat small intestine, which contained extractable NMU. Furthermore, the two NMU receptors were not detected in endocrine rat or human pancreas. We conclude that NMU does not act as a decretin hormone in rats.
Identifiants
pubmed: 30449683
pii: S1550-4131(18)30640-5
doi: 10.1016/j.cmet.2018.10.008
pii:
doi:
Substances chimiques
Insulin
0
Neuropeptides
0
Receptors, Neurotransmitter
0
neuromedin U receptor
0
neuromedin U
117505-80-3
Somatostatin
51110-01-1
Glucagon
9007-92-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
719-726.e5Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.