Representation of spatial sequences using nested rules in human prefrontal cortex.
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
01 02 2019
01 02 2019
Historique:
received:
10
07
2018
revised:
18
10
2018
accepted:
22
10
2018
pubmed:
20
11
2018
medline:
16
7
2019
entrez:
20
11
2018
Statut:
ppublish
Résumé
Memory for spatial sequences does not depend solely on the number of locations to be stored, but also on the presence of spatial regularities. Here, we show that the human brain quickly stores spatial sequences by detecting geometrical regularities at multiple time scales and encoding them in a format akin to a programming language. We measured gaze-anticipation behavior while spatial sequences of variable regularity were repeated. Participants' behavior suggested that they quickly discovered the most compact description of each sequence in a language comprising nested rules, and used these rules to compress the sequence in memory and predict the next items. Activity in dorsal inferior prefrontal cortex correlated with the amount of compression, while right dorsolateral prefrontal cortex encoded the presence of embedded structures. Sequence learning was accompanied by a progressive differentiation of multi-voxel activity patterns in these regions. We propose that humans are endowed with a simple "language of geometry" which recruits a dorsal prefrontal circuit for geometrical rules, distinct from but close to areas involved in natural language processing.
Identifiants
pubmed: 30449729
pii: S1053-8119(18)32033-0
doi: 10.1016/j.neuroimage.2018.10.061
pmc: PMC6592816
mid: EMS83207
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
245-255Subventions
Organisme : European Research Council
ID : 695403
Pays : International
Informations de copyright
Copyright © 2018. Published by Elsevier Inc.
Références
Hum Brain Mapp. 2000 Jul;10(3):120-31
pubmed: 10912591
J Exp Psychol Gen. 2001 Dec;130(4):658-80
pubmed: 11757874
Science. 2002 Nov 22;298(5598):1569-79
pubmed: 12446899
Neuron. 2003 Jan 23;37(2):361-7
pubmed: 12546829
Q J Exp Psychol A. 2003 Jan;56(1):3-30
pubmed: 12587893
Nat Neurosci. 2003 Jul;6(7):674-81
pubmed: 12830158
Science. 2003 Nov 14;302(5648):1181-5
pubmed: 14615530
Science. 2004 Jan 16;303(5656):377-80
pubmed: 14726592
Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3519-24
pubmed: 15713804
Neuron. 2006 Jun 15;50(6):963-74
pubmed: 16772176
Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14240-5
pubmed: 16968771
J Exp Psychol Gen. 2006 Nov;135(4):623-40
pubmed: 17087577
Trends Cogn Sci. 2007 Jun;11(6):229-35
pubmed: 17475536
Psychol Rev. 2007 Apr;114(2):245-72
pubmed: 17500627
BMC Neurosci. 2007 Oct 31;8:91
pubmed: 17973998
Nat Neurosci. 2008 Apr;11(4):426-8
pubmed: 18344993
Front Syst Neurosci. 2008 Nov 24;2:4
pubmed: 19104670
Proc Natl Acad Sci U S A. 2009 May 19;106(20):8362-7
pubmed: 19416819
Cereb Cortex. 2010 Mar;20(3):730-42
pubmed: 19620620
Nat Rev Neurosci. 2009 Sep;10(9):659-69
pubmed: 19672274
Neuron. 2010 Apr 29;66(2):315-26
pubmed: 20435006
Trends Neurosci. 2010 Aug;33(8):355-61
pubmed: 20573407
Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2522-7
pubmed: 21224415
Front Psychol. 2010 Jul 15;1:32
pubmed: 21833202
Hum Brain Mapp. 2012 Aug;33(8):1952-63
pubmed: 21834102
Neuroimage. 2012 Jul 16;61(4):1444-60
pubmed: 22521479
Philos Trans R Soc Lond B Biol Sci. 2012 Jul 19;367(1598):1933-55
pubmed: 22688631
Cognition. 2012 Dec;125(3):475-90
pubmed: 22921187
Cereb Cortex. 2015 Jul;25(7):1815-26
pubmed: 24451658
Neuron. 2014 Feb 5;81(3):700-13
pubmed: 24485097
Cognition. 2014 Aug;132(2):137-50
pubmed: 24809742
Phys Life Rev. 2014 Sep;11(3):329-64
pubmed: 24969660
Front Syst Neurosci. 2014 Nov 25;8:223
pubmed: 25505390
Brain Lang. 2015 Sep;148:25-36
pubmed: 25865749
Curr Biol. 2015 Aug 3;25(15):1966-74
pubmed: 26212883
Neuron. 2015 Sep 23;87(6):1357-1368
pubmed: 26402612
Neuron. 2015 Oct 7;88(1):2-19
pubmed: 26447569
Nat Commun. 2015 Nov 17;6:8901
pubmed: 26573340
Elife. 2016 Mar 21;5:null
pubmed: 26999822
Proc Natl Acad Sci U S A. 2016 May 3;113(18):4909-17
pubmed: 27071124
Neuron. 2016 May 18;90(4):893-903
pubmed: 27196978
J Neurosci. 2016 Oct 5;36(40):10314-10322
pubmed: 27707968
Trends Neurosci. 2017 Feb;40(2):72-82
pubmed: 28063612
PLoS Comput Biol. 2017 Jan 26;13(1):e1005273
pubmed: 28125595
Curr Biol. 2017 May 22;27(10):1549
pubmed: 28535382
Trends Cogn Sci. 2018 Feb;22(2):170-188
pubmed: 29229206
Philos Trans R Soc Lond B Biol Sci. 2017 Feb 19;373(1740):
pubmed: 29292362
J Exp Psychol Hum Percept Perform. 1983 Feb;9(1):86-102
pubmed: 6220126
Neuroimage. 1997 Jan;5(1):49-62
pubmed: 9038284
Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13293-8
pubmed: 9371839
Science. 1999 Jan 1;283(5398):77-80
pubmed: 9872745