Dose-dependent effects of continuous positive airway pressure for sleep apnea on weight or metabolic function: Individual patient-level clinical trial meta-analysis.
continuous positive airway pressure
metabolic function
obstructive sleep apnea
weight
Journal
Journal of sleep research
ISSN: 1365-2869
Titre abrégé: J Sleep Res
Pays: England
ID NLM: 9214441
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
24
07
2018
revised:
18
09
2018
accepted:
09
10
2018
pubmed:
20
11
2018
medline:
29
5
2020
entrez:
20
11
2018
Statut:
ppublish
Résumé
Therapeutic-continuous positive airway pressure seems to increase weight compared with placebo-continuous positive airway pressure. It is not known whether weight gain with therapeutic-continuous positive airway pressure dose is dependent or whether it causes metabolic dysfunction. Data synthesis of three randomised placebo-continuous positive airway pressure-controlled trials (2-3 months) was performed to test whether there is a dose-dependent effect of continuous positive airway pressure on weight. Fasting glucose, insulin, insulin resistance (homeostatic model assessment), lipids and visceral abdominal fat were also tested to determine any effect on metabolic function. Mixed-model analysis of variance was used to quantify these effects. One-hundred and twenty-eight patients were analysed. Overall there was a small increase in weight with therapeutic-continuous positive airway pressure use compared with placebo-continuous positive airway pressure (difference: 1.17 kg; 0.37-1.97, p = 0.005), which was greater with high-use therapeutic-continuous positive airway pressure compared with high-use placebo-continuous positive airway pressure (1.45 kg; 0.10-2.80, p = 0.04). Continuous positive airway pressure use as a continuous variable was also significantly associated with weight change in continuous positive airway pressure users (0.30 kg hr
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12788Informations de copyright
© 2018 European Sleep Research Society.
Références
Borel, A. L., Leblanc, X., Almeras, N., Tremblay, A., Bergeron, J., Poirier, P., … Series, F. (2012). Sleep apnoea attenuates the effects of a lifestyle intervention programme in men with visceral obesity. Thorax, 67, 735-741.
Chirinos, J. A., Gurubhagavatula, I., Teff, K., Rader, D. J., Wadden, T. A., Townsend, R., … Pack, A. I. (2014). CPAP, weight loss, or both for obstructive sleep apnea. New England Journal of Medicine, 370, 2265-2275.
Chopra, S., Rathore, A., Younas, H., Pham, L. V., Gu, C., Beselman, A., … Jun, J. C. (2017). Obstructive sleep apnea dynamically increases nocturnal plasma free fatty acids, glucose, and cortisol during sleep. Journal of Clinical Endocrinology and Metabolism, 102, 3172-3181.
Crawford, M. R., Bartlett, D. J., Coughlin, S. R., Phillips, C. L., Neill, A. M., Espie, C. A., … Marshall, N. S. (2012). The effect of continuous positive airway pressure usage on sleepiness in obstructive sleep apnoea: Real effects or expectation of benefit? Thorax, 67, 920-924.
Drager, L. F., Brunoni, A. R., Jenner, R., Lorenzi-Filho, G., Bensenor, I. M., & Lotufo, P. A. (2015). Effects of CPAP on body weight in patients with obstructive sleep apnoea: A meta-analysis of randomised trials. Thorax, 70, 258-264.
Flegal, K. M., Kit, B. K., Orpana, H., & Graubard, B. I. (2013). Association of all-cause mortality with overweight and obesity using standard body mass index categories: A systematic review and meta-analysis. JAMA, 309, 71-82.
Garcia, J. M., Sharafkhaneh, H., Hirshkowitz, M., Elkhatib, R., & Sharafkhaneh, A. (2011). Weight and metabolic effects of CPAP in obstructive sleep apnea patients with obesity. Respiratory Research, 12, 80.
Hoyos, C. M., Killick, R., Keenan, D. M., Baxter, R. C., Veldhuis, J. D., & Liu, P. Y. (2014). Continuous positive airway pressure increases pulsatile growth hormone secretion and circulating insulin-like growth factor-1 in a time-dependent manner in men with obstructive sleep apnea: A randomized sham-controlled study. Sleep, 37, 733-741.
Hoyos, C. M., Killick, R., Yee, B. J., Phillips, C. L., Grunstein, R. R., & Liu, P. Y. (2012). Cardiometabolic changes after continuous positive airway pressure for obstructive sleep apnoea: A randomised sham-controlled study. Thorax, 67, 1081-1089.
Hoyos, C. M., Phillips, C. L., & Grunstein, R. R. (2014). From couch potato to gym junkie-CPAP may not be the answer. Journal of Clinical Sleep Medicine, 10, 473-474.
Karimi, M., Hedner, J., Lombardi, C., Mcnicholas, W. T., Penzel, T., Riha, R. L., … ESADA Study Group. (2014). Driving habits and risk factors for traffic accidents among sleep apnea patients-a European multi-centre cohort study. Journal of Sleep Research, 23, 689-699.
Marin, J. M., Carrizo, S. J., Vicente, E., & Agusti, A. G. (2005). Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: An observational study. Lancet, 365, 1046-1053.
Martinez-Ceron, E., Barquiel, B., Bezos, A. M., Casitas, R., Galera, R., García-Benito, C., … Garcia-Rio, F. (2016). Effect of continuous positive airway pressure on glycemic control in patients with obstructive sleep apnea and type 2 diabetes. A randomized clinical trial. American Journal of Respiratory and Critical Care Medicine, 194, 476-485.
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985). Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28, 412-419.
Melehan, K. L., Hoyos, C. M., Hamilton, G. S., Wong, K. K., Yee, B. J., McLachlan, R. I., … Liu, P. Y. (2018). Randomised trial of CPAP and Vardenafil on erectile and arterial function in men with obstructive sleep apnea and erectile dysfunction. Journal of Clinical Endocrinology and Metabolism, 103(4), 1601-1611.
Mokhlesi, B., Grimaldi, D., Beccuti, G., Abraham, V., Whitmore, H., Delebecque, F., & Van Cauter, E. (2016). Effect of one week of 8-hour nightly continuous positive airway pressure treatment of obstructive sleep apnea on glycemic control in type 2 diabetes: A Proof-of-Concept Study. American Journal of Respiratory and Critical Care Medicine, 194, 516-519.
Munzer, T., Hegglin, A., Stannek, T., Schoch, O. D., Korte, W., Büche, D., … Hürny, C. (2010). Effects of long-term continuous positive airway pressure on body composition and IGF1. European Journal of Endocrinology, 162, 695-704.
Ong, C. W., O'Driscoll, D. M., Truby, H., Naughton, M. T., & Hamilton, G. S. (2013). The reciprocal interaction between obesity and obstructive sleep apnoea. Sleep Medicine Reviews, 17, 123-131.
Pamidi, S., Wroblewski, K., Stepien, M., Sharif-Sidi, K., Kilkus, J., Whitmore, H., & Tasali, E. (2015). Eight hours of nightly continuous positive airway pressure treatment of obstructive sleep apnea improves glucose metabolism in patients with prediabetes. A randomized controlled trial. American Journal of Respiratory and Critical Care Medicine, 192, 96-105.
Patel, S. R. (2015). The complex relationship between weight and sleep apnoea. Thorax, 70, 205-206.
Peppard, P. E., Young, T., Barnet, J. H., Palta, M., Hagen, E. W., & Hla, K. M. (2013). Increased prevalence of sleep-disordered breathing in adults. American Journal of Epidemiology, 177, 1006-1014.
Peppard, P. E., Young, T., Palta, M., Dempsey, J., & Skatrud, J. (2000). Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA, 284, 3015-3021.
Phillips, C. L., Yee, B. J., Marshall, N. S., Liu, P. Y., Sullivan, D. R., & Grunstein, R. R. (2011). Continuous positive airway pressure reduces post prandial lipidemia in obstructive sleep apnea. A randomised, placebo controlled crossover trial. American Journal of Respiratory and Critical Care Medicine, 184, 355-361.
Quan, S. F., Budhiraja, R., Clarke, D. P., Goodwin, J. L., Gottlieb, D. J., Nichols, D. A., … Kushida, C. A. (2013). Impact of treatment with continuous positive airway pressure (CPAP) on weight in obstructive sleep apnea. Journal of Clinical Sleep Medicine, 9, 989-993.
Quan, S. F., Budhiraja, R., Clarke, D. P., Goodwin, J. L., Gottlieb, D. J., Nichols, D. A., … Phillips, B. (2014). You still need more than CPAP for OSA patients to lose weight. Journal of Clinical Sleep Medicine, 10, 349.
Redenius, R., Murphy, C., O'Neill, E., Al-Hamwi, M., & Zallek, S. N. (2008). Does CPAP lead to change in BMI? Journal of Clinical Sleep Medicine, 20, 5-9.
Shaw, J. E., Punjabi, N. M., Naughton, M. T., Willes, L., Bergenstal, R. M., Cistulli, P. A., … Zimmet, P. Z. (2016). The effect of treatment of obstructive sleep apnea on glycemic control in type 2 diabetes. American Journal of Respiratory and Critical Care Medicine, 194, 486-492.
Sivam, S., Phillips, C. L., Trenell, M. I., Yee, B. J., Liu, P. Y., Wong, K. K., & Grunstein, R. R. (2012). Effects of 8 weeks of continuous positive airway pressure on abdominal adiposity in obstructive sleep apnoea. European Respiratory Journal, 40, 913-918.
Stenlof, K., Grunstein, R., Hedner, J., & Sjostrom, L. (1996). Energy expenditure in obstructive sleep apnea: Effects of treatment with continuous positive airway pressure. American Journal of Physiology, 271, E1036-E1043.
Tachikawa, R., Ikeda, K., Minami, T., Matsumoto, T., Hamada, S., Murase, K., … Chin, K. (2016). Changes in energy metabolism after continuous positive airway pressure for obstructive sleep apnea. American Journal of Respiratory and Critical Care Medicine, 194, 729-738.
Young, T., Peppard, P. E., & Taheri, S. (2005). Excess weight and sleep-disordered breathing. Journal of Applied Physiology, 99, 1592-1599.