On the Mechanisms of Action of the Low Molecular Weight Fraction of Commercial Human Serum Albumin in Osteoarthritis.
CD36
Inflammation
aryl hydrocarbon receptor
cyclooxygenase 2
disease modification
kynurenine.
Journal
Current rheumatology reviews
ISSN: 1875-6360
Titre abrégé: Curr Rheumatol Rev
Pays: United Arab Emirates
ID NLM: 101261938
Informations de publication
Date de publication:
2019
2019
Historique:
received:
27
06
2018
revised:
02
11
2018
accepted:
03
11
2018
pubmed:
20
11
2018
medline:
28
1
2020
entrez:
20
11
2018
Statut:
ppublish
Résumé
The low molecular weight fraction of commercial human serum albumin (LMWF5A) has been shown to successfully relieve pain and inflammation in severe osteoarthritis of the knee (OAK). LMWF5A contains at least three active components that could account for these antiinflammatory and analgesic effects. We summarize in vitro experiments in bone marrow-derived mesenchymal stem cells, monocytic cell lines, chondrocytes, peripheral blood mononuclear cells, fibroblast-like synoviocytes, and endothelial cells on the biochemistry of anti-inflammatory changes induced by LMWF5A. We then look at four of the major pathways that cut across cell-type considerations to examine which biochemical reactions are affected by mTOR, COX-2, CD36, and AhR pathways. All three components show anti-inflammatory activities in at least some of the cell types. The in vitro experiments show that the effects of LMWF5A in chondrocytes and bone marrow- derived stem cells in particular, coupled with recent data from previous clinical trials of single and multiple injections of LMWF5A into OAK patients demonstrated improvements in pain, function, and Patient Global Assessment (PGA), as well as high responder rates that could be attributed to the multiple mechanism of action (MOA) pathways are summarized here. In vitro and in vivo data are highly suggestive of LMWF5A being a disease-modifying drug for OAK.
Identifiants
pubmed: 30451114
pii: CRR-EPUB-94629
doi: 10.2174/1573397114666181119121519
pmc: PMC6791032
doi:
Substances chimiques
Analgesics
0
Anti-Inflammatory Agents
0
Serum Albumin, Human
ZIF514RVZR
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
189-200Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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