A clickable caging group as a new platform for modular caged compounds with improved photochemical properties.
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
03 Jan 2019
03 Jan 2019
Historique:
pubmed:
20
11
2018
medline:
20
11
2018
entrez:
20
11
2018
Statut:
ppublish
Résumé
A 6-bromo-7-hydroxycoumarin-4-ylmethyl (Bhc) caged compound having a click-modifiable chemical handle was designed and synthesized. This molecule was applied to the synthesis of modular caged paclitaxels (PTXs) in which additional functional units could be easily installed. This system was used to prepare water-soluble caged PTXs with improved photolysis efficiencies.
Types de publication
Journal Article
Langues
eng