Gender differences, UV exposure and risk of lentigo maligna in a nationwide healthcare population cohort study.
Journal
Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN: 1468-3083
Titre abrégé: J Eur Acad Dermatol Venereol
Pays: England
ID NLM: 9216037
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
31
08
2018
accepted:
06
11
2018
pubmed:
20
11
2018
medline:
16
1
2020
entrez:
20
11
2018
Statut:
ppublish
Résumé
Our understanding of the relationship between ultraviolet (UV) radiation exposure and lentigo maligna (LM) has been largely derived from epidemiologic/clinical studies based on invasive melanoma. Recent studies have shown gender differences in melanocytic tumours incidence. To examine the association of UV light with LM by gender remains unclear. Two prospective cohort study [Nurses' Health Study (1980-2012)] and [Health Professionals Follow-up Study (1986-2010)] were analysed. All participants with LM or MIS, non-LM type were included in analysis. UV index at birth, age 15, and age 30 were calculated by gender. Lifetime UV flux was calculated. Hazard ratios (HRs) were calculated. A total of 110 485 women from NHS and 41 015 men from HPFS were examined. A total of 281 LM and 776 melanoma in situ (MIS), non-LM cases were reported. Risk of LM increased with increasing UV flux exposure in multivariate-adjusted models for men (P for trend = 0.04), but not for women (P for trend = 0.91). UV flux may be associated with LM in men but not in women.
Sections du résumé
BACKGROUND
BACKGROUND
Our understanding of the relationship between ultraviolet (UV) radiation exposure and lentigo maligna (LM) has been largely derived from epidemiologic/clinical studies based on invasive melanoma. Recent studies have shown gender differences in melanocytic tumours incidence.
OBJECTIVE
OBJECTIVE
To examine the association of UV light with LM by gender remains unclear.
METHODS
METHODS
Two prospective cohort study [Nurses' Health Study (1980-2012)] and [Health Professionals Follow-up Study (1986-2010)] were analysed. All participants with LM or MIS, non-LM type were included in analysis. UV index at birth, age 15, and age 30 were calculated by gender. Lifetime UV flux was calculated. Hazard ratios (HRs) were calculated.
RESULTS
RESULTS
A total of 110 485 women from NHS and 41 015 men from HPFS were examined. A total of 281 LM and 776 melanoma in situ (MIS), non-LM cases were reported. Risk of LM increased with increasing UV flux exposure in multivariate-adjusted models for men (P for trend = 0.04), but not for women (P for trend = 0.91).
CONCLUSIONS
CONCLUSIONS
UV flux may be associated with LM in men but not in women.
Identifiants
pubmed: 30451319
doi: 10.1111/jdv.15348
pmc: PMC6767620
mid: NIHMS1051645
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1268-1271Subventions
Organisme : Career Development Award of Dermatology Foundation
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA167552
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
Organisme : National Institutes of Health
ID : P01 CA87969
Informations de copyright
© 2018 European Academy of Dermatology and Venereology.
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