Secular changes in clinical manifestations of kidney disease among Japanese adults with type 2 diabetes from 1996 to 2014.
Aged
Albuminuria
/ etiology
Biomarkers
/ analysis
Blood Glucose
/ analysis
Cohort Studies
Cross-Sectional Studies
Diabetes Mellitus, Type 2
/ complications
Diabetic Nephropathies
/ epidemiology
Disease Progression
Female
Follow-Up Studies
Glomerular Filtration Rate
Glycated Hemoglobin
/ analysis
Humans
Japan
/ epidemiology
Male
Middle Aged
Prevalence
Prognosis
Risk Factors
Time Factors
albuminuria
diabetic kidney disease
diabetic nephropathy
Journal
Journal of diabetes investigation
ISSN: 2040-1124
Titre abrégé: J Diabetes Investig
Pays: Japan
ID NLM: 101520702
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
05
07
2018
revised:
01
10
2018
accepted:
14
11
2018
pubmed:
20
11
2018
medline:
14
1
2020
entrez:
20
11
2018
Statut:
ppublish
Résumé
Diabetic kidney disease is characterized by increased albuminuria and/or a reduced glomerular filtration rate (GFR). We analyzed secular changes in the prevalence of albuminuria and reduced estimated GFR (eGFR) in Japanese patients with type 2 diabetes, and identified factors associated with these changes. Using 1996, 2001, 2006 and 2014 cohort data from the Japanese serial cross-sectional studies conducted at Shiga University of Medical Science, secular changes in the prevalence of diabetic kidney disease (albuminuria and/or reduced eGFR), patient characteristics and their associations were analyzed. The prevalence of microalbuminuria and macroalbuminuria decreased over time, whereas the prevalence of moderately reduced eGFR (30-60 mL/min/1.73 m During the past 20 years in Japan, the prevalence of albuminuria declined, whereas that of reduced eGFR increased. Additionally, obesity- and high age-related vascular damage seems to be associated with macroalbuminuria and reduced eGFR without macroalbuminuria, respectively.
Identifiants
pubmed: 30451386
doi: 10.1111/jdi.12977
pmc: PMC6626952
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Glycated Hemoglobin A
0
hemoglobin A1c protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1032-1040Informations de copyright
© 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
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