Genetic ablation of Gpr37l1 delays tumor occurrence in Ptch1
Cerebellum
Gpr37l1
Medulloblastoma
Ptch1
Wnt3
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
17
08
2018
revised:
06
11
2018
accepted:
15
11
2018
pubmed:
20
11
2018
medline:
2
5
2019
entrez:
20
11
2018
Statut:
ppublish
Résumé
The G-protein coupled receptor 37-like 1 (Gpr37l1) is specifically expressed in most astrocytic glial cells, including cerebellar Bergmann astrocytes and interacts with patched 1 (Ptch1), a co-receptor of the sonic hedgehog (Shh)-smoothened (Smo) signaling complex. Gpr37l1 null mutant mice exhibit precocious post-natal cerebellar development, with altered Shh-Smo mitogenic cascade and premature down-regulation of granule cell precursor (GCP) proliferation. Gpr37l1 expression is downregulated in medulloblastoma (MB) and upregulated in glioma and glioblastoma tumors. Shh-associated MBs originate postnatally, from dysregulated hyperproliferation of GCPs in developing cerebellum's external granular layer (EGL), as shown in heterozygous Ptch1
Identifiants
pubmed: 30452905
pii: S0014-4886(18)30375-3
doi: 10.1016/j.expneurol.2018.11.004
pii:
doi:
Substances chimiques
Gpr37l1protein, mouse
0
Patched-1 Receptor
0
Ptch1 protein, mouse
0
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
33-42Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.