Legal aspects of zebrafish neuropharmacology and neurotoxicology research.

Animal Experimentation / ethics Animals Central Nervous System Agents / toxicity Controlled Substances Disease Models, Animal Drug Discovery Neuropharmacology / ethics Pain Stress, Physiological Zebrafish
3Rs Animal welfare regulations Pharmacology Toxicology

Journal

Regulatory toxicology and pharmacology : RTP
ISSN: 1096-0295
Titre abrégé: Regul Toxicol Pharmacol
Pays: Netherlands
ID NLM: 8214983

Informations de publication

Date de publication:
Feb 2019
Historique:
received: 10 05 2018
revised: 13 11 2018
accepted: 15 11 2018
pubmed: 20 11 2018
medline: 25 1 2019
entrez: 20 11 2018
Statut: ppublish

Résumé

Despite the growing emphasis on translational neuropharmacology and drug discovery research, the legality underlying these fields are seldom considered. The zebrafish (Danio rerio) is an increasingly utilized model organism in neuropharmacology and neurotoxicology. As the acceptance of zebrafish in biomedicine continues to grow, the legal aspects of their applications remain outpaced by this exponential growth. Therefore, there is a need to evaluate the legal aspects of zebrafish applications to CNS drug research. Here, we discuss a wide range of regulatory topics relevant to zebrafish research, such as the bioethics of experimentation (including studies of stress and pain), welfare protection laws, the recent advances in CNS drug discovery, and specific legal aspects of controlled substance research in this aquatic species. The conceptualization and understanding of the zebrafish welfare and its promise as a model in toxicology can also potentially shape environmental protection practices and inform policy making.

Identifiants

DOI: 10.1016/j.yrtph.2018.11.007 PMID: 30453007
pubmed: 30453007
pii: S0273-2300(18)30299-X
doi: 10.1016/j.yrtph.2018.11.007
pii:
doi:

Substances chimiques

Central Nervous System Agents 0
Controlled Substances 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

65-70

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Murilo S de Abreu (MS)

Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA. Electronic address: abreu_murilo@hotmail.com.

Ana C V V Giacomini (ACVV)

Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Postgraduate Program in Environmental Sciences, University of Passo Fundo (UPF), Passo Fundo, Brazil.

David J Echevarria (DJ)

The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA; ZENEREI Research Center, Slidell, LA, USA.

Allan V Kalueff (AV)

School of Pharmacy, Southwest University, Chongqing, China; Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; Ural Federal University, Ekaterinburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Granov Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia. Electronic address: avkalueff@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Expérimentation animale › Legal aspects of zebrafish neuropharmacology...
questionsmedicales.fr › Eucaryotes › Animaux › Legal aspects of zebrafish neuropharmacology...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Legal aspects of zebrafish neuropharmacology...
questionsmedicales.fr › Préparations pharmaceutiques › Substances réglementées › Legal aspects of zebrafish neuropharmacology...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Legal aspects of zebrafish neuropharmacology...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Legal aspects of zebrafish neuropharmacology...
questionsmedicales.fr › Professions de santé › Pharmacologie › Neuropharmacologie › Legal aspects of zebrafish neuropharmacology...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › Legal aspects of zebrafish neuropharmacology...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Legal aspects of zebrafish neuropharmacology...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Legal aspects of zebrafish neuropharmacology...