Toxicological safety evaluation in acute and 28-day studies of aqueous extract from Serjania marginata Casar. (Sapindaceae) leaves in rats.
Acute toxicity
Reproductive parameters
Serjania marginata
Subacute toxicity
Journal
Journal of ethnopharmacology
ISSN: 1872-7573
Titre abrégé: J Ethnopharmacol
Pays: Ireland
ID NLM: 7903310
Informations de publication
Date de publication:
01 Mar 2019
01 Mar 2019
Historique:
received:
07
05
2018
revised:
26
09
2018
accepted:
14
11
2018
pubmed:
20
11
2018
medline:
26
2
2019
entrez:
20
11
2018
Statut:
ppublish
Résumé
Serjania marginata Casar. (Sapindaceae) is a species traditionally known to be used for the treatment of gastric pain and inflammatory symptoms. Due to the therapeutic importance of this species, this study investigated the toxicological effects of S. marginata leaves (AESM), after a single and a repeated exposure in rats. For the acute toxicity test, 2000 mg/kg of AESM was administered to male and female rats by gavage, whereas for subacute toxicity test, 30, 150, or 750 mg/kg of AESM were used. No evidence of toxicity was observed in the animals acutely exposed to the extract, indicating that the LD Although AESM was not toxic after a single exposure, its use after prolonged periods affected some analyzed parameters, indicating that precautions should be taken when it is given over longer periods.
Identifiants
pubmed: 30453050
pii: S0378-8741(18)31687-8
doi: 10.1016/j.jep.2018.11.024
pii:
doi:
Substances chimiques
Phytochemicals
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
197-204Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.