Childhood Obesity and the Metabolic Syndrome.

Adolescent Child Humans Metabolic Syndrome / complications Pediatric Obesity / complications Renal Insufficiency, Chronic / diagnosis Risk Factors
Bariatric surgery Metabolic syndrome Obesity-related glomerulopathy Obesity-related kidney disease

Journal

Pediatric clinics of North America
ISSN: 1557-8240
Titre abrégé: Pediatr Clin North Am
Pays: United States
ID NLM: 0401126

Informations de publication

Date de publication:
02 2019
Historique:
entrez: 21 11 2018
pubmed: 21 11 2018
medline: 30 1 2019
Statut: ppublish

Résumé

Obesity is a leading cause of chronic kidney disease. Children with severe obesity have an increased prevalence of early kidney abnormalities and are at high risk to develop kidney failure in adulthood. The pathophysiology of obesity-related kidney disease is incompletely understood, although the postulated mechanisms of kidney injury include hyperfiltration, adipokine dysregulation, and lipotoxic injury. An improved understanding of the long-term effects of obesity on kidney health is essential treat the growing epidemic of obesity-related kidney disease. The purpose of this article is to review the epidemiology, pathophysiology, clinical features, and management of obesity-related kidney disease in children and adolescents.

Identifiants

DOI: 10.1016/j.pcl.2018.08.004 PMID: 30454749
pubmed: 30454749
pii: S0031-3955(18)30128-7
doi: 10.1016/j.pcl.2018.08.004
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

31-43

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Edward Nehus (E)

Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7022, Cincinnati, OH 45229, USA. Electronic address: edward.nehus@cchmc.org.

Mark Mitsnefes (M)

Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7022, Cincinnati, OH 45229, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Childhood Obesity and the Metabolic Syndrome.
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Childhood Obesity and the Metabolic Syndrome.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Childhood Obesity and the Metabolic Syndrome.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Syndrome métabolique X › Childhood Obesity and the Metabolic Syndrome.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Obésité pédiatrique › Childhood Obesity and the Metabolic Syndrome.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Insuffisance rénale chronique › Childhood Obesity and the Metabolic Syndrome.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Childhood Obesity and the Metabolic Syndrome.