Postpregnancy BMI in the Progression From Hypertensive Disorders of Pregnancy to Type 2 Diabetes.
Adult
Blood Pressure
Body Mass Index
Diabetes Mellitus, Type 2
/ diagnosis
Diabetes, Gestational
/ diagnosis
Disease Progression
Female
Follow-Up Studies
Humans
Hypertension, Pregnancy-Induced
/ diagnosis
Incidence
Life Style
Middle Aged
Obesity
/ diagnosis
Pre-Eclampsia
/ epidemiology
Pregnancy
Proportional Hazards Models
Prospective Studies
Risk Factors
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
17
07
2018
accepted:
05
10
2018
pubmed:
21
11
2018
medline:
3
5
2019
entrez:
21
11
2018
Statut:
ppublish
Résumé
To study the extent to which BMI after pregnancy adds to the elevated risk of postpregnancy type 2 diabetes in women with a history of hypertensive disorders of pregnancy (HDP) (preeclampsia or gestational hypertension). We used data from the Nurses' Health Study II, a prospective cohort study. In women aged 45-54 years without prior gestational diabetes mellitus, we investigated the interaction between BMI and HDP history on the risk of type 2 diabetes. For clinical and public health relevance, we focused on additive interaction. The main outcome measure was the relative excess risk due to interaction calculated from multivariable Cox proportional hazards models using normal weight as the reference group. In total, 6,563 (11.7%) of 56,159 participants had a history of HDP and 1,341 women developed type 2 diabetes during 436,333 person-years. BMI was a strong risk factor for type 2 diabetes regardless of HDP history. However, there was evidence of an additive interaction between BMI and HDP for the risk of type 2 diabetes ( Maintaining a healthy weight may be of even greater importance in women with a history of HDP, compared with other women with a history of only normotensive pregnancies, to reduce midlife risk of type 2 diabetes.
Identifiants
pubmed: 30455328
pii: dc18-1532
doi: 10.2337/dc18-1532
pmc: PMC6300702
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
44-49Subventions
Organisme : NHLBI NIH HHS
ID : F31 HL131222
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL098048
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA176726
Pays : United States
Informations de copyright
© 2018 by the American Diabetes Association.
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