Adipose Tissue Insulin Resistance in Youth on the Spectrum From Normal Weight to Obese and From Normal Glucose Tolerance to Impaired Glucose Tolerance to Type 2 Diabetes.
Adipose Tissue
/ metabolism
Adiposity
/ physiology
Adolescent
Blood Glucose
/ metabolism
Child
Cohort Studies
Diabetes Mellitus, Type 2
/ complications
Female
Glucose
/ metabolism
Glucose Intolerance
/ complications
Glucose Tolerance Test
Humans
Ideal Body Weight
/ physiology
Insulin
/ metabolism
Insulin Resistance
/ physiology
Male
Pediatric Obesity
/ complications
Young Adult
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
30
05
2018
accepted:
25
10
2018
pubmed:
21
11
2018
medline:
25
7
2019
entrez:
21
11
2018
Statut:
ppublish
Résumé
Adipose tissue insulin resistance is one of the pathophysiological components of type 2 diabetes. Herein we investigated: A total of 205 youth had fasting glucose, insulin, FFA, Adipose-IR, body composition, visceral adipose tissue (VAT), leptin, and adiponectin evaluated. Adipose-IR was 2.2-fold higher in obese NGT, 4.3-fold higher in IGT, and 4.6-fold higher in type 2 diabetes compared with that in normal-weight peers (all Adipose-IR is a simple surrogate estimate that reflects pathophysiological alterations in adipose tissue insulin sensitivity in youth, with progressive deterioration from normal weight to obese and from NGT to IGT to type 2 diabetes. Adipose-IR can be applied in large-scale epidemiological/observational studies of the natural history of youth-onset type 2 diabetes and its progression or reversal with intervention strategies.
Identifiants
pubmed: 30455334
pii: dc18-1178
doi: 10.2337/dc18-1178
pmc: PMC6341282
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Pagination
265-272Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR000005
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024153
Pays : United States
Organisme : NICHD NIH HHS
ID : K24 HD001357
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007052
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD027503
Pays : United States
Informations de copyright
© 2018 by the American Diabetes Association.
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