Posttransplant Characterization of Long-term Functional hESC-Derived Pancreatic Endoderm Grafts.


Journal

Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763

Informations de publication

Date de publication:
May 2019
Historique:
received: 18 07 2018
accepted: 06 11 2018
pubmed: 21 11 2018
medline: 4 7 2019
entrez: 21 11 2018
Statut: ppublish

Résumé

The paucity of human donors limits broadened application of β-cell replacement therapy. Insulin-producing cells derived from human embryonic stem cells (hESCs) have recently been investigated clinically as a feasible surrogate to primary tissue. Herein, we examine the long-term efficacy of hESC-derived pancreatic endoderm cells (PECs) to maintain normoglycemia posttransplant and characterize the phenotype of the PEC grafts. Mice with chemically induced diabetes were transplanted with PECs into the subcutaneous device-less site. Transplant function was assessed through nonfasting blood glucose measurements, intraperitoneal glucose tolerance testing (IPGTT), and human C-peptide secretion for 517 days. Explanted grafts were assessed for ex vivo function and immunohistochemically. All PEC recipients (

Identifiants

pubmed: 30455375
pii: db18-0788
doi: 10.2337/db18-0788
doi:

Substances chimiques

Blood Glucose 0
C-Peptide 0
Insulin 0

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

953-962

Commentaires et corrections

Type : CommentIn
Type : CommentOn

Informations de copyright

© 2019 by the American Diabetes Association.

Auteurs

Andrew R Pepper (AR)

Clinical Islet Transplant Program, University of Alberta, Edmonton, Alberta, Canada.
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.

Antonio Bruni (A)

Clinical Islet Transplant Program, University of Alberta, Edmonton, Alberta, Canada.
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.

Rena Pawlick (R)

Clinical Islet Transplant Program, University of Alberta, Edmonton, Alberta, Canada.

Doug O'Gorman (D)

Clinical Islet Transplant Program, University of Alberta, Edmonton, Alberta, Canada.

Tatsuya Kin (T)

Clinical Islet Transplant Program, University of Alberta, Edmonton, Alberta, Canada.

Aducio Thiesen (A)

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.

A M James Shapiro (AMJ)

Clinical Islet Transplant Program, University of Alberta, Edmonton, Alberta, Canada amjs@islet.ca.
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.

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Classifications MeSH