Valproic acid exerts specific cellular and molecular anti-inflammatory effects in post-operative conjunctiva.
Animals
Anti-Inflammatory Agents
/ therapeutic use
Cells, Cultured
Conjunctiva
/ drug effects
Cytokines
/ analysis
Female
Fibroblasts
/ drug effects
Glaucoma
/ pathology
Inflammation
/ drug therapy
Macrophages
/ drug effects
Male
Mice
Mice, Inbred C57BL
NF-kappa B
/ analysis
Postoperative Care
Valproic Acid
/ therapeutic use
Conjunctiva
Glaucoma filtration surgery
Histone deacetylase inhibitor
Inflammation
NF-kB
TNF-α
Valproic acid
Journal
Journal of molecular medicine (Berlin, Germany)
ISSN: 1432-1440
Titre abrégé: J Mol Med (Berl)
Pays: Germany
ID NLM: 9504370
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
24
04
2018
accepted:
09
11
2018
revised:
08
10
2018
pubmed:
21
11
2018
medline:
6
5
2020
entrez:
21
11
2018
Statut:
ppublish
Résumé
Valproic acid (VPA) is a histone deacetylase inhibitor used clinically for neurological disorders. It is also potentially useful as anti-fibrotic therapy as it reduced collagen deposition in the post-operative conjunctiva. In this study, we further evaluated the effects of VPA on post-operative inflammation using the mouse model of conjunctival scarring. VPA, injected into the subconjunctiva immediately after surgery, did not cause any adverse tissue response when examined by live microscopy and produced an apparent reduction of proinflammatory and proangiogenic markers in immunohistological examinations. In-depth analyses of the treated operated tissues revealed that VPA selectively inhibited the CD45
Identifiants
pubmed: 30456449
doi: 10.1007/s00109-018-1722-x
pii: 10.1007/s00109-018-1722-x
pmc: PMC6326969
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Cytokines
0
NF-kappa B
0
Valproic Acid
614OI1Z5WI
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
63-75Subventions
Organisme : National Medical Research Council
ID : NMRC/NIG/0055/2009
Pays : International
Organisme : National Medical Research Council
ID : NMRC/CSA-SI/0001/2015
Pays : International
Organisme : National Medical Research Council
ID : NMRC/TCR/002-SERI/2008
Pays : International
Organisme : National Medical Research Council
ID : NMRC/TCR/008-SERI/2013
Pays : International
Organisme : National Medical Research Council
ID : NMRC/CG/015/2013
Pays : International
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