Dexmedetomidine alleviates cerebral ischemia-reperfusion injury in rats via inhibition of hypoxia-inducible factor-1α.
cell apoptosis
cerebral ischemia-reperfusion
dexmedetomidine (Dex)
hypoxia-inducible factor-1α (HIF-1α)
Journal
Journal of cellular biochemistry
ISSN: 1097-4644
Titre abrégé: J Cell Biochem
Pays: United States
ID NLM: 8205768
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
18
07
2018
accepted:
22
10
2018
pubmed:
21
11
2018
medline:
21
11
2018
entrez:
21
11
2018
Statut:
ppublish
Résumé
Dexmedetomidine (Dex) was reported to reduce ischemia-reperfusion (I/R) injury in kidney and brain tissues. Thus, we aimed to study the role and mechanism of Dex in cerebral I/R injury by inhibiting hypoxia-inducible factor-1α (HIF-1α) and apoptosis. First, I/R injury models were established. Six groups were assigned after different treatments: sham, I/R, I/R+Dex, I/R+2-methoxyestradiol (2ME2) (HIF-1α inhibitor), I/R+CoCl
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7834-7844Informations de copyright
© 2018 Wiley Periodicals, Inc.