Tongguan capsule-derived herb reduces susceptibility to atrial fibrillation by inhibiting left atrial fibrosis via modulating cardiac fibroblasts.
Animals
Anti-Arrhythmia Agents
/ administration & dosage
Apoptosis
Atrial Fibrillation
/ pathology
Capsules
/ administration & dosage
Cell Cycle
Cell Movement
Cell Proliferation
Cells, Cultured
Drugs, Chinese Herbal
/ chemistry
Fibroblasts
/ cytology
Fibrosis
/ drug therapy
Heart Atria
/ drug effects
Heart Rate
Male
Rats
Rats, Sprague-Dawley
Chinese medicine
atrial fibrillation
atrium
fibroblasts
fibrosis
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
08
08
2018
revised:
11
10
2018
accepted:
16
10
2018
pubmed:
21
11
2018
medline:
1
7
2020
entrez:
21
11
2018
Statut:
ppublish
Résumé
Tongguan capsule is a compound Chinese medicine used to treat ischaemic heart diseases. This study aimed to investigate whether Tongguan capsule-derived herb (TGD) has a preventive effect on atrial fibrillation (AF) in post-myocardial infarction (MI) rats and to determine the underlying mechanisms. MI was induced by ligation of the left anterior descending coronary artery. TGD was administered to the post-MI rats over a 4-week period. The TGD-treated rats had lower rates of AF inducibility and shorter AF durations than the MI rats. TGD improved the left atrial (LA) conduction velocity and homogeneity. It reduced the fibrosis-positive areas and the protein levels of collagen types I and III in the left atrium. In vitro, it inhibited the expression of collagen types I and III by inhibiting the proliferation, migration, differentiation and cytokine secretion of cardiac fibroblasts (CFs). In conclusion, the current study demonstrated that TGD reduces susceptibility to AF and improves LA conduction function in rats with post-MI by inhibiting left atrial fibrosis and modulating CFs. Targeting the CF population may be a novel antiarrhythmic therapeutic approach.
Identifiants
pubmed: 30456908
doi: 10.1111/jcmm.14022
pmc: PMC6349173
doi:
Substances chimiques
Anti-Arrhythmia Agents
0
Capsules
0
Drugs, Chinese Herbal
0
tongguan
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1197-1210Informations de copyright
© 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
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