Neurological manifestations in Onchocerca volvulus infection: A review.
Epilepsy
Neurological features
Onchocerca volvulus
Journal
Brain research bulletin
ISSN: 1873-2747
Titre abrégé: Brain Res Bull
Pays: United States
ID NLM: 7605818
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
17
04
2018
revised:
22
08
2018
accepted:
25
08
2018
pubmed:
21
11
2018
medline:
17
1
2020
entrez:
21
11
2018
Statut:
ppublish
Résumé
Human onchocerciasis, caused by infection by the filarial nematode Onchocerca volvulus, is a major neglected public health problem that affects millions of people in the endemic regions of sub-Saharan Africa and Latin America. Onchocerciasis is known to be associated with skin and eye disease and more recently, neurological features have been recognized as a major manifestation. Especially the latter poses a severe burden on affected individuals and their families. Although definite studies are awaited, preliminary evidence suggests that neurological disease may include the nodding syndrome, Nakalanga syndrome and epilepsy but to date, the exact pathophysiological mechanisms remain unclear. Currently, the only way to prevent Onchocera volvulus associated disease is through interventions that target the elimination of onchocerciasis through community distribution of ivermectin and larviciding the breeding sites of the Similium or blackfly vector in rivers. In this review, we discuss the epidemiology, potential pathological mechanisms as well as prevention and treatment strategies of onchocerciasis, focusing on the neurological disease.
Identifiants
pubmed: 30458251
pii: S0361-9230(18)30288-0
doi: 10.1016/j.brainresbull.2018.08.024
pmc: PMC6382410
pii:
doi:
Substances chimiques
Ivermectin
70288-86-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
39-44Subventions
Organisme : Medical Research Council
ID : MR/M025489/1
Pays : United Kingdom
Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
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