Differential Role of Hypothalamic AMPKα Isoforms in Fish: an Evolutive Perspective.
AMPK isoforms
Food intake
Hepatic metabolism
Hypothalamus
Trout
Journal
Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
08
08
2018
accepted:
15
11
2018
pubmed:
22
11
2018
medline:
15
1
2020
entrez:
22
11
2018
Statut:
ppublish
Résumé
In mammals, hypothalamic AMP-activated protein kinase (AMPK) α1 and α2 isoforms mainly relate to regulation of thermogenesis/liver metabolism and food intake, respectively. Since both isoforms are present in fish, which do not thermoregulate, we assessed their role(s) in hypothalamus regarding control of food intake and energy homeostasis. Since many fish species are carnivorous and mostly mammals are omnivorous, assessing if the role of hypothalamic AMPK is different is also an open question. Using the rainbow trout as a fish model, we first observed that food deprivation for 5 days did not significantly increase phosphorylation status of AMPKα in hypothalamus. Then, we administered adenoviral vectors that express dominant negative (DN) AMPKα1 or AMPKα2 isoforms. The inhibition of AMPKα2 (but not AMPKα1) led to decreased food intake. The central inhibition of AMPKα2 resulted in liver with decreased capacity of use and synthesis of glucose, lipids, and amino acids suggesting that a signal of nutrient abundance flows from hypothalamus to the liver, thus suggesting a role for central AMPKα2 in the regulation of peripheral metabolism in fishes. The central inhibition of AMPKα1 induced comparable changes in liver metabolism though at a lower extent. From an evolutionary point of view, it is of interest that the function of central AMPKα2 remained similar throughout the vertebrate lineage. In contrast, the function of central AMPKα1 in fish relates to modulation of liver metabolism whereas in mammals modulates not only liver metabolism but also brown adipose tissue and thermogenesis.
Identifiants
pubmed: 30460617
doi: 10.1007/s12035-018-1434-9
pii: 10.1007/s12035-018-1434-9
doi:
Substances chimiques
Isoenzymes
0
AMP-Activated Protein Kinases
EC 2.7.11.31
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5051-5066Subventions
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : AGL2016-74857-C3-1-R
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : SAF2015-71026-R
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : IJCI-2016-30499
Organisme : Ministerio de Educación, Cultura y Deporte
ID : FPU16/00045
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