A sequence conserved between CD5 and CD6 binds an FERM domain and exerts a restraint on T-cell activation.
Actins
/ immunology
Animals
Antibodies, Monoclonal
/ immunology
Antigens, CD
/ immunology
Antigens, Differentiation, T-Lymphocyte
/ immunology
CD5 Antigens
/ immunology
Cell Membrane
/ immunology
Cytoplasm
/ immunology
Cytoskeleton
/ immunology
DNA-Binding Proteins
/ immunology
Humans
Lymphocyte Activation
/ immunology
Phosphorylation
/ immunology
Rats
T-Lymphocytes
/ immunology
Tyrosine
/ immunology
T cell
inhibitory/activating receptors
signal transduction
Journal
Immunology
ISSN: 1365-2567
Titre abrégé: Immunology
Pays: England
ID NLM: 0374672
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
22
10
2018
accepted:
14
11
2018
pubmed:
22
11
2018
medline:
30
8
2019
entrez:
22
11
2018
Statut:
ppublish
Résumé
CD5 and CD6 are related surface receptors that limit and promote T-cell responses. Co-stimulatory effects of CD6 depend on binding a cell surface ligand, CD166, and recruitment of the intracellular adaptor proteins GADS and SLP-76 by C-terminal phosphotyrosines. We have continued to identify interactions of CD5 and CD6 to understand their roles in T-cell activation. In a screen to identify binding partners for peptides containing a cytoplasmic sequence, SDSDY conserved between CD5 and CD6, we identified ezrin radixin moesin (ERM) proteins, which link plasma membrane proteins to actin. Purified radixin FERM domain bound directly to CD5 and CD6 SDSDY peptides in a phosphorylation-dependent manner (K
Identifiants
pubmed: 30460991
doi: 10.1111/imm.13025
pmc: PMC6376265
doi:
Substances chimiques
Actins
0
Antibodies, Monoclonal
0
Antigens, CD
0
Antigens, Differentiation, T-Lymphocyte
0
CD5 Antigens
0
CD6 antigen
0
DNA-Binding Proteins
0
Tyrosine
42HK56048U
Banques de données
GENBANK
['NP_001093259', 'HSU34623']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
270-276Subventions
Organisme : Medical Research Council
ID : G0400808
Pays : United Kingdom
Informations de copyright
© 2018 The Authors. Immunology Published by John Wiley & Sons Ltd.
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