Expression of β-catenin in human trophoblast and its role in placenta accreta and placenta previa.
birth weight
pathogenesis
placenta
placenta accreta
placenta previa
trophoblastic invasion
trophoblasts
β-catenin
Journal
The Journal of international medical research
ISSN: 1473-2300
Titre abrégé: J Int Med Res
Pays: England
ID NLM: 0346411
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
pubmed:
23
11
2018
medline:
8
6
2019
entrez:
23
11
2018
Statut:
ppublish
Résumé
To investigate the expression of β-catenin in chorionic villi, and to explore its roles in placenta accreta and placenta previa. We compared β-catenin expression in the control group, placenta accreta group (lesion area and normal zones), and placenta previa group (placental central and placental edge zones) by immunohistochemistry, Western blotting, and RT-PCR techniques. Compared with the normal group, the placenta accreta group had a longer length of stay, greater bleeding volume, and lower newborn birth weight. Further, the expression of β-catenin was lower in both placenta previa and placenta accreta groups than in the control group, as measured by immunohistochemistry. Compared with the control group, expression of β-catenin was significantly lower in the placenta previa and placenta accreta groups by Western blotting and RT-PCR. Importantly, the level of placental β-catenin was significantly different when compared between the lesion and normal zones of placenta. The expression of β-catenin in placenta accreta might play an important role in the regulation of placental cell invasion; low expression of β-catenin in placenta accreta might be responsible for excessive trophoblastic invasion.
Identifiants
pubmed: 30465458
doi: 10.1177/0300060518799265
pmc: PMC6384477
doi:
Substances chimiques
CTNNB1 protein, human
0
beta Catenin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
206-214Références
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