Nanomedicine and macroscale materials in immuno-oncology.
Journal
Chemical Society reviews
ISSN: 1460-4744
Titre abrégé: Chem Soc Rev
Pays: England
ID NLM: 0335405
Informations de publication
Date de publication:
02 Jan 2019
02 Jan 2019
Historique:
pubmed:
23
11
2018
medline:
11
1
2019
entrez:
23
11
2018
Statut:
ppublish
Résumé
Immunotherapy is revolutionizing the treatment of cancer. It can achieve unprecedented responses in advanced-stage patients, including complete cures and long-term survival. However, immunotherapy also has limitations, such as its relatively low response rates and the development of severe side effects. These drawbacks are gradually being overcome by improving our understanding of the immune system, as well as by establishing combination regimens in which immunotherapy is combined with other treatment modalities. In addition to this, in recent years, progress made in chemistry, nanotechnology and materials science has started to impact immuno-oncology, resulting in more effective and less toxic immunotherapy interventions. In this context, multiple different nanomedicine formulations and macroscale materials have been shown to be able to boost anti-cancer immunity and the efficacy of immunomodulatory drugs. We here review nanotechnological and materials chemistry efforts related to endogenous and exogenous vaccination, to the engineering of antigen-presenting cells and T cells, and to the modulation of the tumor microenvironment. We also discuss limitations, current trends and future directions. Together, the insights provided and the evidence obtained indicate that there is a bright future ahead for engineering nanomedicines and macroscale materials for immuno-oncology applications.
Identifiants
pubmed: 30465669
doi: 10.1039/c8cs00473k
pmc: PMC7115880
mid: EMS87685
doi:
Substances chimiques
Macromolecular Substances
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
351-381Subventions
Organisme : European Research Council
ID : 813086
Pays : International
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