Orthobiologics for Focal Articular Cartilage Defects.

Adipose Tissue / cytology Allografts Biological Products / therapeutic use Bone Marrow Cartilage / transplantation Cartilage Diseases / therapy Humans Knee Joint Mesenchymal Stem Cell Transplantation Platelet-Rich Plasma
Cartilage defect Cartilage restoration Cartilage transplant Orthobiologics PRP Stem cells

Journal

Clinics in sports medicine
ISSN: 1556-228X
Titre abrégé: Clin Sports Med
Pays: United States
ID NLM: 8112473

Informations de publication

Date de publication:
Jan 2019
Historique:
entrez: 24 11 2018
pubmed: 24 11 2018
medline: 14 12 2018
Statut: ppublish

Résumé

Focal chondral defects of the knee are extremely common and often result in pain, dysfunction, joint deterioration, and, ultimately, the development of osteoarthritis. Due to the limitations of conventional treatments for focal chondral defects of the knee, orthobiologics have recently become an area of interest. Orthobiologics used for cartilage defects include (but are not limited to) bone marrow aspirate concentrate, adipose-derived mesenchymal stem cells, platelet-rich plasma, and micronized allogeneic cartilage. Each of these products can be applied in the clinical setting, as an isolated surgical procedure, or as an augment to cartilage restoration surgery.

Identifiants

DOI: 10.1016/j.csm.2018.09.001 PMID: 30466717
pubmed: 30466717
pii: S0278-5919(18)30084-X
doi: 10.1016/j.csm.2018.09.001
pii:
doi:

Substances chimiques

Biological Products 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

109-122

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Taylor M Southworth (TM)

Department of Orthopedics, Rush University Medical Center, 1611 West Harrison, Suite 300, Chicago, IL 60612, USA.

Neal B Naveen (NB)

Department of Orthopedics, Rush University Medical Center, 1611 West Harrison, Suite 300, Chicago, IL 60612, USA.

Benedict U Nwachukwu (BU)

Department of Orthopedics, Rush University Medical Center, 1611 West Harrison, Suite 300, Chicago, IL 60612, USA.

Brian J Cole (BJ)

Department of Orthopedics, Rush University Medical Center, 1611 West Harrison, Suite 300, Chicago, IL 60612, USA.

Rachel M Frank (RM)

Sports Medicine and Shoulder Surgery, Department of Orthopaedic Surgery, University of Colorado School of Medicine, 12631 East 17th Avenue, Mail Stop B202, Aurora, CO 80045, USA. Electronic address: rachel.frank@ucdenver.edu.

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Classifications MeSH

questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Orthobiologics for Focal Articular Cartilage Defects.
questionsmedicales.fr › Régions du corps › Transplants › Allogreffes › Orthobiologics for Focal Articular Cartilage Defects.
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Orthobiologics for Focal Articular Cartilage Defects.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Moelle osseuse › Orthobiologics for Focal Articular Cartilage Defects.
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › Orthobiologics for Focal Articular Cartilage Defects.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies du tissu conjonctif › Maladies du cartilage › Orthobiologics for Focal Articular Cartilage Defects.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Orthobiologics for Focal Articular Cartilage Defects.
questionsmedicales.fr › Appareil locomoteur › Squelette › Articulations › Articulation du genou › Orthobiologics for Focal Articular Cartilage Defects.
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches mésenchymateuses › Orthobiologics for Focal Articular Cartilage Defects.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Plasma sanguin › Plasma riche en plaquettes › Orthobiologics for Focal Articular Cartilage Defects.