Adipose-Derived Stem Cell Treatments and Formulations.

Adipose Tissue / cytology Cartilage Diseases / therapy Clinical Trials as Topic Humans Injections, Intra-Articular Stem Cells / cytology
Adipose-derived mesenchymal stem cells Cartilage Intra-articular injection Osteoarthritis Stem cells Stromal vascular fraction

Journal

Clinics in sports medicine
ISSN: 1556-228X
Titre abrégé: Clin Sports Med
Pays: United States
ID NLM: 8112473

Informations de publication

Date de publication:
Jan 2019
Historique:
entrez: 24 11 2018
pubmed: 24 11 2018
medline: 14 12 2018
Statut: ppublish

Résumé

This article analyzes the current literature on the use of adipose-derived stem cells (ASCs) to evaluate the available evidence regarding their therapeutic potential in the treatment of cartilage pathology. Seventeen articles were included and analyzed, showing that there is overall a lack of high-quality evidence concerning the use of ASCs. Most trials are case series with short-term evaluation. The most adopted approach consists of an intra-articular injection of the stromal vascular fraction (SVF) rather than the expanded cells. Based on the available data, no specific preparation method or formulation could be considered as the preferred choice in clinical practice.

Identifiants

DOI: 10.1016/j.csm.2018.08.004 PMID: 30466723
pubmed: 30466723
pii: S0278-5919(18)30076-0
doi: 10.1016/j.csm.2018.08.004
pii:
doi:

Types de publication

Journal Article Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

61-78

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Berardo Di Matteo (B)

Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, Rozzano, Milan 20089, Italy; Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, Milan 20089, Italy. Electronic address: berardo.dimatteo@gmail.com.

Mohamed Marzouk El Araby (MM)

Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, Rozzano, Milan 20089, Italy; Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, Milan 20089, Italy.

Alessandro D'Angelo (A)

Department of Orthopaedic, Traumatology and Rehabilitation, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, Turin 10126, Italy.

Francesco Iacono (F)

Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, Rozzano, Milan 20089, Italy; Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, Milan 20089, Italy.

Alessandra Nannini (A)

Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, Rozzano, Milan 20089, Italy; Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, Milan 20089, Italy.

Nicolò Danilo Vitale (ND)

Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, Rozzano, Milan 20089, Italy; Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, Milan 20089, Italy.

Maurilio Marcacci (M)

Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, Rozzano, Milan 20089, Italy; Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, Milan 20089, Italy.

Stefano Respizzi (S)

Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, Rozzano, Milan 20089, Italy; Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, Milan 20089, Italy.

Elizaveta Kon (E)

Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, Rozzano, Milan 20089, Italy; Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, Milan 20089, Italy.

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Classifications MeSH

questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Adipose-Derived Stem Cell Treatments and Formulations.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies du tissu conjonctif › Maladies du cartilage › Adipose-Derived Stem Cell Treatments and Formulations.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Adipose-Derived Stem Cell Treatments and Formulations.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Adipose-Derived Stem Cell Treatments and Formulations.
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections articulaires › Adipose-Derived Stem Cell Treatments and Formulations.
questionsmedicales.fr › Cellules › Cellules souches › Adipose-Derived Stem Cell Treatments and Formulations.