Ortho-Biologics for Ligament Repair and Reconstruction.

Animals Biological Products / therapeutic use Bone Marrow Cell Differentiation Extracellular Matrix Fibroblasts / cytology Humans Hyaluronic Acid / therapeutic use Intercellular Signaling Peptides and Proteins / therapeutic use Ligaments / injuries Mesenchymal Stem Cells / cytology Platelet-Rich Plasma
Anterior cruciate ligament Bone marrow aspirate concentrate Growth factor Platelet-rich plasma Transforming growth factor

Journal

Clinics in sports medicine
ISSN: 1556-228X
Titre abrégé: Clin Sports Med
Pays: United States
ID NLM: 8112473

Informations de publication

Date de publication:
Jan 2019
Historique:
entrez: 24 11 2018
pubmed: 24 11 2018
medline: 14 12 2018
Statut: ppublish

Résumé

Biologics enhance tissue healing by stimulating the recovery processes for restoration of native or near-native tissue in addition to symptom management. The most popular biological modalities currently used include hyaluronic acid, growth factors therapy, platelet-rich plasma, and bone marrow aspirate concentrate. These treatment protocols are thought to facilitate and signal with cells or bioactive factors to improve ligament interventions by enhanced graft incorporation and strength, gene activation, and other mechanisms. Various growth factors regulate and improve cellular activities and proliferation, extracellular matrix deposition, and differentiation of mesenchymal stem cells into fibroblasts in the repair process of torn ligaments.

Identifiants

DOI: 10.1016/j.csm.2018.08.003 PMID: 30466725
pubmed: 30466725
pii: S0278-5919(18)30075-9
doi: 10.1016/j.csm.2018.08.003
pii:
doi:

Substances chimiques

Biological Products 0
Intercellular Signaling Peptides and Proteins 0
Hyaluronic Acid 9004-61-9

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

97-107

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Jorge Chahla (J)

Sports Medicne and Shoulder Service, Midwest Orthopaedics at Rush, 1611 Harrison Avenue, Suite 300, Chicago, IL 60612, USA. Electronic address: jachahla@msn.com.

Mitchell I Kennedy (MI)

The Steadman Philippon Research Institute, 181 West Meadow Drive, Suite 400, Vail, CO 81657, USA.

Zach S Aman (ZS)

The Steadman Philippon Research Institute, 181 West Meadow Drive, Suite 400, Vail, CO 81657, USA.

Robert F LaPrade (RF)

The Steadman Clinic, 181 West Meadow Drive, Suite 400, Vail, CO 81657, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Ortho-Biologics for Ligament Repair and Reconstruction.
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Ortho-Biologics for Ligament Repair and Reconstruction.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Moelle osseuse › Ortho-Biologics for Ligament Repair and Reconstruction.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Ortho-Biologics for Ligament Repair and Reconstruction.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Matrice extracellulaire › Ortho-Biologics for Ligament Repair and Reconstruction.
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Ortho-Biologics for Ligament Repair and Reconstruction.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ortho-Biologics for Ligament Repair and Reconstruction.
questionsmedicales.fr › Glucides › Polyosides › Glycosaminoglycanes › Acide hyaluronique › Ortho-Biologics for Ligament Repair and Reconstruction.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Ortho-Biologics for Ligament Repair and Reconstruction.
questionsmedicales.fr › Tissus › Tissu conjonctif › Ligaments › Ortho-Biologics for Ligament Repair and Reconstruction.
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Ortho-Biologics for Ligament Repair and Reconstruction.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Plasma sanguin › Plasma riche en plaquettes › Ortho-Biologics for Ligament Repair and Reconstruction.