A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis.
Alzheimer's disease
Amyloid
Cerebrospinal fluid (CSF)
Model
Nonhuman primate
Tau
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
12
02
2018
revised:
18
06
2018
accepted:
28
06
2018
pubmed:
24
11
2018
medline:
19
7
2019
entrez:
24
11
2018
Statut:
ppublish
Résumé
Nonhuman primates may serve as excellent models of sporadic age-associated brain β-amyloid deposition and Alzheimer's disease pathologic changes. We examined whether a vervet nonhuman primate model recapitulated pathologic, physiologic, and behavioral features of early Alzheimer's disease. Nine middle-aged (mean = 11.2 years) and nine aged (mean = 21.7 years) female vervet/African green monkeys underwent cerebrospinal fluid collection, gait speed measurement, and neuroimaging before neuropathologic assessment. β-amyloid plaques were identified in all aged vervets and paired helical filament tau immunoreactivity was observed in all animals. Cerebrospinal fluid β-amyloid We observed a coordinated set of relationships among neuropathologic, cerebrospinal fluid, imaging, and behavioral modalities consistent with early Alzheimer's disease. Our results support future use of the vervet model to explore disease mechanisms, biomarkers, and novel therapeutic strategies.
Identifiants
pubmed: 30467082
pii: S1552-5260(18)33246-1
doi: 10.1016/j.jalz.2018.06.3057
pmc: PMC6383152
mid: NIHMS1513084
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
93-105Subventions
Organisme : NIH HHS
ID : P40 OD010965
Pays : United States
Organisme : NIH HHS
ID : T32 OD010957
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005136
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG049638
Pays : United States
Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
Références
ILAR J. 2013;54(2):122-43
pubmed: 24174437
Front Neuroinform. 2012 Dec 06;6:27
pubmed: 23230398
Neurology. 1991 Apr;41(4):479-86
pubmed: 2011243
Neurobiol Aging. 1995 May-Jun;16(3):271-8; discussion 278-84
pubmed: 7566337
J Gerontol A Biol Sci Med Sci. 2013 Aug;68(8):929-37
pubmed: 23250002
J Am Geriatr Soc. 2017 Apr;65(4):792-799
pubmed: 27869301
J Neurosci. 2018 Jan 17;38(3):530-543
pubmed: 29192126
Exp Neurol. 2000 May;163(1):98-110
pubmed: 10785448
Neurobiol Aging. 2013 Oct;34(10):2361-9
pubmed: 23601810
Am J Pathol. 2004 Jul;165(1):283-97
pubmed: 15215183
Acta Neuropathol Commun. 2013 Oct 09;1:65
pubmed: 24252435
Neurology. 2002 Jun 25;58(12):1791-800
pubmed: 12084879
Am J Pathol. 1990 Dec;137(6):1383-92
pubmed: 1701963
J Neuropathol Exp Neurol. 2000 Aug;59(8):733-48
pubmed: 10952063
Neuroinformatics. 2014 Oct;12(4):543-50
pubmed: 24850577
Neuroimage. 2002 Sep;17(1):302-16
pubmed: 12482085
Brain Behav. 2018 Jan 13;8(2):e00903
pubmed: 29484263
Psychosom Med. 2008 Jul;70(6):637-45
pubmed: 18596246
J Nucl Med. 2004 Feb;45(2):192-201
pubmed: 14960635
Neuroimage. 2011 Feb 1;54(3):1872-80
pubmed: 20923706
Science. 1987 Feb 20;235(4791):873-7
pubmed: 3544219
J Neurosci. 2016 Apr 13;36(15):4248-58
pubmed: 27076423
Neurology. 2008 Aug 12;71(7):499-504
pubmed: 18695161
Psychopharmacology (Berl). 2014 Apr;231(7):1409-16
pubmed: 24193371
Neurobiol Aging. 2017 Nov;59:107-120
pubmed: 28888720
J Alzheimers Dis. 2017;56(2):763-774
pubmed: 28035921
Neuroinformatics. 2016 Apr;14(2):183-90
pubmed: 26643442
Arch Gerontol Geriatr. 2017 Nov;73:148-153
pubmed: 28818760
Am J Pathol. 1994 Jun;144(6):1183-7
pubmed: 8203459
Neuroimage. 2003 Jul;19(3):1233-9
pubmed: 12880848
J Nucl Med. 2002 Sep;43(9):1157-66
pubmed: 12215553
Neuropathol Appl Neurobiol. 1986 Jan-Feb;12(1):3-9
pubmed: 2422580
Neurobiol Aging. 2015 Oct;36(10):2798-805
pubmed: 26195068
JAMA Neurol. 2017 Jan 1;74(1):82-90
pubmed: 27842173
Neurosci Biobehav Rev. 2016 May;64:326-45
pubmed: 26915926
Med Image Anal. 2008 Feb;12(1):26-41
pubmed: 17659998
Age (Dordr). 2012 Oct;34(5):1123-31
pubmed: 22203457
Brain. 2016 May;139(Pt 5):1551-67
pubmed: 26962052
J Cereb Blood Flow Metab. 1983 Mar;3(1):1-7
pubmed: 6822610
Neuroimage Clin. 2013 Jan 24;2:249-57
pubmed: 24179779
Nucl Med Commun. 2011 Dec;32(12):1121-7
pubmed: 21946619
Front Aging Neurosci. 2014 Nov 10;6:313
pubmed: 25426069
Alzheimers Dement. 2018 Jun;14(6):703-706
pubmed: 29842864
Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):5036-41
pubmed: 24707050
Trends Mol Med. 2017 Jun;23(6):534-545
pubmed: 28483344
Neurobiol Aging. 2008 Aug;29(8):1143-59
pubmed: 17428581
Neuroimage. 2004;23 Suppl 1:S139-50
pubmed: 15501083
JAMA Neurol. 2013 May;70(5):616-22
pubmed: 23552688
Alzheimers Dement. 2012 Jan;8(1):1-13
pubmed: 22265587
Acta Neuropathol. 2012 Jan;123(1):1-11
pubmed: 22101365
Alzheimers Dement. 2018 May;14(5):680-691
pubmed: 29241829
J Neurosci. 2014 Oct 8;34(41):13629-43
pubmed: 25297091