Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities.
computational biology
heterogeneous data
machine learning
personalized medicine
systems biology
Journal
An international journal on information fusion
ISSN: 1566-2535
Titre abrégé: Inf Fusion
Pays: Netherlands
ID NLM: 101513488
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
entrez:
24
11
2018
pubmed:
24
11
2018
medline:
24
11
2018
Statut:
ppublish
Résumé
New technologies have enabled the investigation of biology and human health at an unprecedented scale and in multiple dimensions. These dimensions include myriad properties describing genome, epigenome, transcriptome, microbiome, phenotype, and lifestyle. No single data type, however, can capture the complexity of all the factors relevant to understanding a phenomenon such as a disease. Integrative methods that combine data from multiple technologies have thus emerged as critical statistical and computational approaches. The key challenge in developing such approaches is the identification of effective models to provide a comprehensive and relevant systems view. An ideal method can answer a biological or medical question, identifying important features and predicting outcomes, by harnessing heterogeneous data across several dimensions of biological variation. In this Review, we describe the principles of data integration and discuss current methods and available implementations. We provide examples of successful data integration in biology and medicine. Finally, we discuss current challenges in biomedical integrative methods and our perspective on the future development of the field.
Identifiants
pubmed: 30467459
doi: 10.1016/j.inffus.2018.09.012
pmc: PMC6242341
mid: NIHMS1510475
doi:
Types de publication
Journal Article
Langues
eng
Pagination
71-91Subventions
Organisme : NIBIB NIH HHS
ID : U54 EB020405
Pays : United States
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