Population level changes in schistosome-specific antibody levels following chemotherapy.
Animals
Anthelmintics
/ therapeutic use
Antibodies, Helminth
/ blood
Humans
Immunity, Humoral
/ drug effects
Praziquantel
/ therapeutic use
Schistosoma haematobium
/ drug effects
Schistosoma mansoni
/ drug effects
Schistosomiasis
/ drug therapy
Schistosomiasis haematobia
/ drug therapy
Schistosomiasis mansoni
/ immunology
antibody levels
human
meta-analysis
population
praziquantel
schistosomiasis
Journal
Parasite immunology
ISSN: 1365-3024
Titre abrégé: Parasite Immunol
Pays: England
ID NLM: 7910948
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
22
06
2018
accepted:
13
11
2018
pubmed:
24
11
2018
medline:
24
5
2019
entrez:
24
11
2018
Statut:
ppublish
Résumé
Previous studies have reported that chemotherapy of schistosomiasis by praziquantel in humans boosts protective antibody responses against S mansoni and S haematobium. A number of studies have reported schistosome-specific antibody levels before and after chemotherapy. Using these reports, a meta-analysis was conducted to identify predictors of population level change in schistosome-specific antibody levels after chemotherapy. Following a systematic review, 92 observations from 26 articles published between 1988 and 2013 were included in this study. Observations were grouped by antigen type and antibody isotypes for the classification and regression tree (CART) analysis. The study showed that the change in antibody levels was variable: (a) between different human populations and (b) according to the parasite antigen and antibody isotypes. Thus, while anti-worm responses predominantly increased after chemotherapy, anti-egg responses decreased or did not show a significant trend. The change in antibody levels depended on a combination of age and infection intensity for anti-egg IgA, IgM, IgG1, IgG2 and anti-worm IgM and IgG. The study results are consistent with praziquantel treatment boosting anti-worm antibody responses. However, there is considerable heterogeneity in post-treatment changes in specific antibody levels that is related to host age and pre-treatment infection intensity.
Identifiants
pubmed: 30467873
doi: 10.1111/pim.12604
pmc: PMC6492179
doi:
Substances chimiques
Anthelmintics
0
Antibodies, Helminth
0
Praziquantel
6490C9U457
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12604Subventions
Organisme : Japan Student Services Organization
Pays : International
Organisme : Wellcome Trust
ID : WT082028MA
Pays : United Kingdom
Organisme : Thrasher Research Fund
ID : 9150
Pays : International
Informations de copyright
© 2018 The Authors. Parasite Immunology Published by John Wiley & Sons Ltd.
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