Synthesis, in vitro stability, and antiproliferative effect of d-cysteine modified GnRH-doxorubicin conjugates.
Animals
Antibiotics, Antineoplastic
/ chemistry
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Cross-Linking Reagents
/ chemistry
Cytotoxins
/ chemistry
Doxorubicin
/ analogs & derivatives
Drug Carriers
Drug Stability
Gene Expression
Gonadotropin-Releasing Hormone
/ analogs & derivatives
Humans
MCF-7 Cells
Maleimides
/ chemistry
Mice
NIH 3T3 Cells
Oligopeptides
/ chemical synthesis
Protein Binding
Receptors, LHRH
/ genetics
Succinimides
/ chemistry
antitumor activity
gonadotropin-releasing hormone
metabolic stability
peptide-drug conjugate
synthesis
Journal
Journal of peptide science : an official publication of the European Peptide Society
ISSN: 1099-1387
Titre abrégé: J Pept Sci
Pays: England
ID NLM: 9506309
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
05
07
2018
revised:
15
09
2018
accepted:
17
10
2018
pubmed:
24
11
2018
medline:
26
2
2019
entrez:
24
11
2018
Statut:
ppublish
Résumé
Overexpression of gonadotropin-releasing hormone (GnRH) receptor in many tumors but not in normal tissues makes it possible to use GnRH analogs as targeting peptides for selective delivery of cytotoxic agents, which may help to enhance the uptake of anticancer drugs by cancer cells and reduce toxicity to normal cells. The GnRH analogs [d-Cys
Substances chimiques
Antibiotics, Antineoplastic
0
Cross-Linking Reagents
0
Cytotoxins
0
Drug Carriers
0
Maleimides
0
Oligopeptides
0
Receptors, LHRH
0
Succinimides
0
succinimidyl 3-N-maleimidopropionate
0
Gonadotropin-Releasing Hormone
33515-09-2
Doxorubicin
80168379AG
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3135Subventions
Organisme : Scientific Research Projects in Colleges and Universities of Hebei Province Education Department
ID : BJ2017055
Organisme : Natural Science Foundation of Hebei Province
ID : H2017406022
Organisme : Undergraduate innovation and entrepreneurship training program of Chengde Medical University
ID : 201721
Organisme : Key Discipline Construction Projects of Hebei Province Higher School
ID : [2013]4
Organisme : Scientific Research Projects in Colleges and Universities of Hebei Province
ID : BJ2017055
Informations de copyright
© 2018 European Peptide Society and John Wiley & Sons, Ltd.