Buccal epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture (BEES-HAUS) procedure: A novel cell therapy-based pilot study.
Adult
Aged
Cell- and Tissue-Based Therapy
/ methods
Endoscopy
/ methods
Humans
Male
Middle Aged
Mouth Mucosa
/ transplantation
Pilot Projects
Plastic Surgery Procedures
/ methods
Recurrence
Tissue Scaffolds
Treatment Outcome
Urethra
/ diagnostic imaging
Urethral Stricture
/ diagnostic imaging
Urologic Surgical Procedures, Male
/ methods
buccal mucosa
cell therapy
scaffold
urethral stenosis
urethral stricture
Journal
International journal of urology : official journal of the Japanese Urological Association
ISSN: 1442-2042
Titre abrégé: Int J Urol
Pays: Australia
ID NLM: 9440237
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
18
01
2018
accepted:
09
10
2018
pubmed:
24
11
2018
medline:
25
6
2019
entrez:
24
11
2018
Statut:
ppublish
Résumé
To describe the feasibility of a novel cell-based endoscopic technique using buccal epithelium, expanded and encapsulated in a thermoreversible gelation polymer scaffold for the treatment of urethral stricture. Six male patients with bulbar urethral stricture ranging from 2.0 to 3.5 cm in length were included in this pilot study. Autologous buccal epithelial cells from a small buccal mucosal biopsy were isolated, cultured and encapsulated in thermoreversible gelation polymer scaffold, and were implanted at the stricture site after a wide endoscopic urethrotomy. All the patients voided well, with a mean peak flow rate of 24 mL/s. Urethroscopy carried out at 6 months showed healthy mucosa at the urethrotomy site. However, two of the six patients had recurrence at 18 and 24 months, respectively. This endoscopic-based Buccal epithelium Expanded and Encapsulated in Scaffold-Hybrid Approach to Urethral Stricture (BEES-HAUS) technique is a promising alternative for the open substitution buccal graft urethroplasty. It is possible to achieve the benefits of open substitution buccal urethroplasty with this endoscopic technique.
Identifiants
pubmed: 30468021
doi: 10.1111/iju.13852
pmc: PMC7379713
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
253-257Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2018 The Authors. International Journal of Urology published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association.
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