Methionine
albumin-adducts
alkylation
high-resolution mass spectrometry
methionyl sulfonium
sulfur mustard
Journal
Drug testing and analysis
ISSN: 1942-7611
Titre abrégé: Drug Test Anal
Pays: England
ID NLM: 101483449
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
03
10
2018
revised:
15
11
2018
accepted:
16
11
2018
pubmed:
24
11
2018
medline:
14
8
2019
entrez:
24
11
2018
Statut:
ppublish
Résumé
Exposure to the vesicant sulfur mustard (SM) may lead to erythema and blistering. Toxicity of SM is hypothesized due to the alkylation of DNA bases and nucleophilic amino acid side chains in proteins (adducts) by forming the hydroxyethylthioethyl (HETE) moiety. Despite its prohibition by the chemical weapons convention, SM still represents a serious threat to military personnel and civilians. Therefore, development and improvement of forensic analytical methods for the verification of SM exposure is of high interest. Protein adducts have been shown to be highly suitable and beneficial biomarkers of poisoning. Herein we present methionine
Substances chimiques
Chemical Warfare Agents
0
Methionine
AE28F7PNPL
Mustard Gas
T8KEC9FH9P
Serum Albumin, Human
ZIF514RVZR
Types de publication
Journal Article
Langues
eng
Pagination
659-668Informations de copyright
© 2018 John Wiley & Sons, Ltd.