Maternal lipid profile differs by gestational diabetes physiologic subtype.
Gestational diabetes
Insulin secretion
Insulin sensitivity
Lipids
Non-esterified fatty acids
Journal
Metabolism: clinical and experimental
ISSN: 1532-8600
Titre abrégé: Metabolism
Pays: United States
ID NLM: 0375267
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
14
09
2018
revised:
02
11
2018
accepted:
14
11
2018
pubmed:
24
11
2018
medline:
18
5
2019
entrez:
24
11
2018
Statut:
ppublish
Résumé
To characterize lipid profiles in women with different gestational diabetes mellitus (GDM) physiologic subtypes. We measured seven lipid markers (total cholesterol, LDL, HDL, triglycerides, non-esterified fatty acids (NEFA), ApoA, ApoB) in fasting plasma collected in a prospective cohort of 805 pregnant women during second trimester. We estimated insulin sensitivity and secretion using oral glucose tolerance test-based validated indices. We categorized GDM physiologic subtypes by insulin sensitivity and secretion defects defined as values below the 25th percentile among women with normal glucose tolerance (NGT), as previously established. We compared lipid markers across NGT and GDM subtypes. We explored associations between lipid markers and newborn anthropometry in the overall group and stratified by glucose tolerance status. Among 805 women, 67 (8.3%) developed GDM. Women with GDM had higher body mass index (BMI; 29.3 vs. 26.6 kg/m Women with GDM have distinct lipid profiles based on their GDM physiologic subtype which may not be apparent when investigating GDM as a single group.
Identifiants
pubmed: 30468781
pii: S0026-0495(18)30247-6
doi: 10.1016/j.metabol.2018.11.008
pmc: PMC8058811
mid: NIHMS1692244
pii:
doi:
Substances chimiques
Biomarkers
0
Lipids
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
39-42Subventions
Organisme : NIDDK NIH HHS
ID : K23 DK113218
Pays : United States
Organisme : CIHR
ID : MOP 115071
Pays : Canada
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
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